Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides

Ian Hazelden; Xiao-Feng Ma; T Langer; John Bower

doi:10.1002/anie.201605152

Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides

Ian Hazelden, Xiao-Feng Ma, T Langer, John Bower

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Abstract

Aza-Heck cyclizations initiated by oxidative addition of Pd⁰-catalysts into the N−O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza-Heck reaction developed to date, provide direct access to diverse N-heterocyclic ring systems.

Original language	English
Pages (from-to)	11198-11202
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	37
Early online date	27 Jul 2016
DOIs	https://doi.org/10.1002/anie.201605152
Publication status	Published - 5 Sept 2016

Keywords

aza-Heck reaction
cascade reactions
N-heterocycles
palladium

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This is the final published version of the article (version of record). It first appeared online via Wiley at http://dx.doi.org/10.1002/anie.201605152. Please refer to any applicable terms of use of the publisher.
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This is the final published version of the article (version of record). It first appeared online via Wiley at http://dx.doi.org/10.1002/anie.201605152. Please refer to any applicable terms of use of the publisher.
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A 13C NMR Coldprobe to Underpin Chemistry Research.
Butts, C. P. (Principal Investigator)
28/02/14 → 29/11/17
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
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Cite this

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AU - Hazelden, Ian

AU - Ma, Xiao-Feng

AU - Langer, T

AU - Bower, John

PY - 2016/9/5

Y1 - 2016/9/5

N2 - Aza-Heck cyclizations initiated by oxidative addition of Pd0-catalysts into the N−O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza-Heck reaction developed to date, provide direct access to diverse N-heterocyclic ring systems.

AB - Aza-Heck cyclizations initiated by oxidative addition of Pd0-catalysts into the N−O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza-Heck reaction developed to date, provide direct access to diverse N-heterocyclic ring systems.

KW - aza-Heck reaction

KW - cascade reactions

KW - N-heterocycles

KW - palladium

U2 - 10.1002/anie.201605152

DO - 10.1002/anie.201605152

M3 - Article (Academic Journal)

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ER -

Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides

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Keywords

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A 13C NMR Coldprobe to Underpin Chemistry Research.

3-month Core Capability for Chemistry Research

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