Diversity and environmental adaptation of phagocytic cell metabolism

Luke C Davies, Christopher M Rice, Daniel W McVicar, Jonathan M Weiss*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

31 Downloads (Pure)

Abstract

Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation-key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils-heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases.

Original languageEnglish
Pages (from-to)37-48
Number of pages12
JournalJournal of Leukocyte Biology
Volume105
Issue number1
Early online date14 Sep 2018
DOIs
Publication statusPublished - 27 Dec 2020

Bibliographical note

©2018 The Authors. Society for Leukocyte Biology Published by Wiley Periodicals, Inc.

Keywords

  • Adaptation, Physiological
  • Animals
  • Humans
  • Macrophages/metabolism
  • Metabolic Networks and Pathways
  • Neoplasms/metabolism
  • Neutrophils/metabolism
  • Phagocytes/metabolism

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