DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly

BH Ozer, B Smarsly, M Antionietti, CFJ Faul

Research output: Contribution to journalArticle (Academic Journal)peer-review

24 Citations (Scopus)

Abstract

Here we show that ionic self-assembly of simple biological tectons can be used to synthesize stable and highly ordered molecular structures. In particular, nucleotides and charged polypeptides can be assembled to form a complex analogous to DNA under relatively benign conditions. The combination of polylysine and pure dGMP leads to a fourfold ladder structure stabilizing an interior G-quartet structure by four polypeptide scaffolds. Making use of the Watson–Crick GC base pairing motive leads to double-stranded complexes. Interestingly, these complexes show stable DNA-like organization in aqueous solutions, as proven by gel electrophoresis and intercalation experiments.
Translated title of the contributionDNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly
Original languageEnglish
Pages (from-to)329 - 336
Number of pages8
JournalSoft Matter
Volume2 (4)
DOIs
Publication statusPublished - Apr 2006

Bibliographical note

Publisher: Royal Society of Chemistry

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