Projects per year
Abstract
5-year survival rate for childhood acute lymphoblastic leukemia (ALL) has risen to approximately 90%,
yet the causal disease pathway is still poorly understood. Evidence suggests multiple ‘hits’ are required
for disease progression; an initial genetic abnormality followed by additional secondary ‘hits’. It is
plausible that environmental influences may trigger these secondary hits, and with the peak incidence
of diagnosis between 2-5 years of age, early life exposures are likely to be key. DNA methylation can
be modified by many environmental exposures and is dramatically altered in cancers, including
childhood ALL. Here we explore the potential that DNA methylation may be involved in the causal
pathway toward disease by acting as a mediator between established environmental factors and
childhood ALL development.
Original language | English |
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Pages (from-to) | 519-536 |
Number of pages | 18 |
Journal | Epigenomics |
Volume | 8 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2016 |
Research Groups and Themes
- ICEP
Keywords
- acute lymphoblastic leukemia
- alcohol
- birth weight
- caffeine
- developmental Programming
- DNA methylation
- environment
- folate
- iron
- smoking
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Dive into the research topics of 'DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia'. Together they form a unique fingerprint.Projects
- 1 Finished
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MRC UoB UNITE Unit - Programme 2
Relton, C. L. (Principal Investigator) & Relton, C. L. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research