DNA methylation networks underlying mammalian traits

Amin Haghani; Caesar Z. Li; Todd R.  Robeck; Joshua Zhang; Ake T Lu; Gareth Jones; et al

doi:10.1126/science.abq5693

DNA methylation networks underlying mammalian traits

Amin Haghani^*, Caesar Z. Li, Todd R. Robeck, Joshua Zhang, Ake T Lu, Gareth Jones, et al

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

54 Citations (Scopus)

Abstract

DNA methylation installs a methyl group to cytosine, placing an epigenetic mark that regulates gene expression. Comparative epigenomics combines epigenetic signatures with phylogenetic relationships to understand species characteristics. Haghani et al. evaluated methylation levels in highly conserved DNA sequences, profiling ~15,000 samples across 348 mammalian species (see the Perspective by de Mendoza). Phylogenetic trees suggest that the divergence of DNA methylation profiles closely mirrors genetic evolution. Species with longer maximum life spans have developed tidier methylation patterns within the genome, characterized by unique peaks and troughs of methylation. Methylation patterns associated with maximum life spans generally differ from those connected to age or interventions that affect mortality risk in mice. These data provide a rich resource of information for fields including evolutionary biology and longevity research. —Di Jiang

Original language	English
Article number	eabq5693
Number of pages	16
Journal	Science
Volume	381
Issue number	6658
DOIs	https://doi.org/10.1126/science.abq5693
Publication status	Published - 11 Aug 2023

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@article{60bdcf62c4194689a22992dc99f02bc1,

title = "DNA methylation networks underlying mammalian traits",

abstract = "DNA methylation installs a methyl group to cytosine, placing an epigenetic mark that regulates gene expression. Comparative epigenomics combines epigenetic signatures with phylogenetic relationships to understand species characteristics. Haghani et al. evaluated methylation levels in highly conserved DNA sequences, profiling ~15,000 samples across 348 mammalian species (see the Perspective by de Mendoza). Phylogenetic trees suggest that the divergence of DNA methylation profiles closely mirrors genetic evolution. Species with longer maximum life spans have developed tidier methylation patterns within the genome, characterized by unique peaks and troughs of methylation. Methylation patterns associated with maximum life spans generally differ from those connected to age or interventions that affect mortality risk in mice. These data provide a rich resource of information for fields including evolutionary biology and longevity research. —Di Jiang",

author = "Amin Haghani and Li, {Caesar Z.} and Robeck, {Todd R.} and Joshua Zhang and Lu, {Ake T} and Gareth Jones and et al",

year = "2023",

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doi = "10.1126/science.abq5693",

language = "English",

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issn = "0036-8075",

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TY - JOUR

T1 - DNA methylation networks underlying mammalian traits

AU - Haghani, Amin

AU - Li, Caesar Z.

AU - Robeck, Todd R.

AU - Zhang, Joshua

AU - Lu, Ake T

AU - Jones, Gareth

AU - al, et

PY - 2023/8/11

Y1 - 2023/8/11

N2 - DNA methylation installs a methyl group to cytosine, placing an epigenetic mark that regulates gene expression. Comparative epigenomics combines epigenetic signatures with phylogenetic relationships to understand species characteristics. Haghani et al. evaluated methylation levels in highly conserved DNA sequences, profiling ~15,000 samples across 348 mammalian species (see the Perspective by de Mendoza). Phylogenetic trees suggest that the divergence of DNA methylation profiles closely mirrors genetic evolution. Species with longer maximum life spans have developed tidier methylation patterns within the genome, characterized by unique peaks and troughs of methylation. Methylation patterns associated with maximum life spans generally differ from those connected to age or interventions that affect mortality risk in mice. These data provide a rich resource of information for fields including evolutionary biology and longevity research. —Di Jiang

AB - DNA methylation installs a methyl group to cytosine, placing an epigenetic mark that regulates gene expression. Comparative epigenomics combines epigenetic signatures with phylogenetic relationships to understand species characteristics. Haghani et al. evaluated methylation levels in highly conserved DNA sequences, profiling ~15,000 samples across 348 mammalian species (see the Perspective by de Mendoza). Phylogenetic trees suggest that the divergence of DNA methylation profiles closely mirrors genetic evolution. Species with longer maximum life spans have developed tidier methylation patterns within the genome, characterized by unique peaks and troughs of methylation. Methylation patterns associated with maximum life spans generally differ from those connected to age or interventions that affect mortality risk in mice. These data provide a rich resource of information for fields including evolutionary biology and longevity research. —Di Jiang

UR - https://digitalcommons.unl.edu/cgi/viewcontent.cgi?params=/context/animalscifacpub/article/2263/&path_info=Haghani_SCIENCE_2023_DNA_methylation_networks.pdf

U2 - 10.1126/science.abq5693

DO - 10.1126/science.abq5693

M3 - Article (Academic Journal)

C2 - 37561875

SN - 0036-8075

VL - 381

JO - Science

JF - Science

IS - 6658

M1 - eabq5693

ER -

DNA methylation networks underlying mammalian traits

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