Do miRNAs have a deep evolutionary history?

James E. Tarver*, Philip C. J. Donoghue, Kevin J. Peterson

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

68 Citations (Scopus)

Abstract

The recent discovery of microRNAs (miRNAs) in unicellular eukaryotes, including miRNAs known previously only from animals or plants, implies that miRNAs have a deep evolutionary history among eukaryotes. This contrasts with the prevailing view that miRNAs evolved convergently in animals and plants. We re-evaluate the evidence and find that none of the 73 plant and animal miRNAs described from protists meet the required criteria for miRNA annotation and, by implication, animals and plants did not acquire any of their respective miRNA genes from the crown ancestor of eukaryotes. Furthermore, of the 159 novel miRNAs previously identified among the seven species of unicellular protists examined, only 28 from the algae Ectocarpus and Chlamydomonas, meet the criteria for miRNA annotation. Therefore, at present only five groups of eukaryotes are known to possess miRNAs, indicating that miRNAs have evolved independently within eukaryotes through exaptation of their shared inherited RNAi machinery.

Original languageEnglish
Pages (from-to)857-866
Number of pages10
JournalBioEssays
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 2012

Keywords

  • plant
  • GIARDIA-INTESTINALIS
  • METAZOAN MICRORNAS
  • MICRORNA GENES
  • PROTOZOAN PARASITES
  • eukaryote
  • ALGA CHLAMYDOMONAS-REINHARDTII
  • microRNA evolution
  • protist
  • CAENORHABDITIS-ELEGANS
  • REGULATORY ROLES
  • SMALL RNAS
  • TRICHOMONAS-VAGINALIS
  • ARABIDOPSIS-THALIANA
  • animal

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