Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?

Clive H Orchard, Simon M Bryant, Andrew F James

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)

Abstract

The transverse (t-) tubules of mammalian ventricular myocytes are invaginations of the surface membrane. The function of many of the key proteins involved in excitation-contraction coupling is located predominantly at the t-tubules, which thus form a Ca handling micro-environment that is central to the normal rapid activation and relaxation of the ventricular myocyte. Although cellular arrhythmogenesis shares many ion flux pathways with normal excitation-contraction coupling, the role of the t-tubules in such arrhythmogenesis has not previously been considered. In this brief review we consider how the location and co-location of proteins at the t-tubules may contribute to the generation of arrhythmogenic delayed and early after-depolarisations, and how the loss of t-tubules that occurs during heart failure may alter the generation of such arrhythmias, as well as contributing to other types of arrhythmia as a result of changes of electrical heterogeneity within the whole heart.
Original languageEnglish
Pages (from-to)4141-4147
Number of pages7
JournalJournal of Physiology
Volume591
Issue number17
DOIs
Publication statusPublished - 7 May 2013

Keywords

  • BETA-ADRENERGIC STIMULATION
  • SPONTANEOUS CALCIUM-RELEASE
  • NA+-CA2+ EXCHANGE ACTIVITY
  • EARLY AFTERDEPOLARIZATIONS
  • SARCOPLASMIC-RETICULUM
  • CA2+ RELEASE
  • HEART-FAILURE
  • RYANODINE RECEPTORS
  • TRANSVERSE TUBULES
  • REDUCED SYNCHRONY

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