Do we understand any more about bladder interstitial cells?-ICI-RS 2013

Anthony Kanai*, Christopher Fry, Ann Hanna-Mitchell, Lori Birder, Irina Zabbarova, Dominika Bijos, Youko Ikeda

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)

9 Citations (Scopus)

Abstract

Aims To present a brief review on discussions from Do we understand any more about lower urinary tract interstitial cells? session at the 2013 International Consultation on Incontinence-Research Society (ICI-RS) meeting in Bristol, UK. Methods Discussion focused on bladder interstitial cell (IC) subtypes, their localization and characterization, and communication between themselves, the urothelium, and detrusor smooth muscle. The role of ICs in bladder pathologies and new methods for studying ICs were also addressed. Results ICs have been studied extensively in the lower urinary tract and have been characterized based on comparisons with ICs of Cajal in the gastro-intestinal tract. In fetal bladders it is believed that ICs drive intrinsic contractions to expel urine through the urachus. These contractions diminish postpartum as bladder innervation develops. Voiding in human neonates occurs when filling triggers a spinal cord reflex that contracts the detrusor; in rodents, maternal stimulation of the perineum triggers voiding. Following spinal cord injury, intrinsic contractions, and spinal micturition reflexes develop, similar to those seen during neonatal development. These enhanced contractions may stimulate nociceptive and mechanosensitive afferents contributing to neurogenic detrusor overactivity and incontinence. The IC-mediated activity is believed to be initiated in the lamina propria by responding to urothelial factors. These IC may act syncytially through gap junction coupling and modulate detrusor activity through unknown mechanisms. Conclusion There has been a great deal of information discovered regarding bladder ICs, however, many of their (patho)physiological functions and mechanisms are still unclear and necessitates further research. Neurourol. Urodynam. 33:573-576, 2014. (c) 2014 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalNeurourology and Urodynamics
Volume33
Issue number5
DOIs
Publication statusPublished - Jun 2014

Keywords

  • detrusor overactivity
  • interstitial cells
  • lamina propria
  • LUTS
  • GUINEA-PIG BLADDER
  • SPINAL-CORD-INJURY
  • URINARY-BLADDER
  • SUBUROTHELIAL MYOFIBROBLASTS
  • OVERACTIVE BLADDER
  • HUMAN DETRUSOR
  • GAP-JUNCTIONS
  • ATP RELEASE
  • CAJAL
  • EXPRESSION

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