Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study

Mika Kivimäki, Debbie A Lawlor, George Davey Smith, Meena Kumari, Ann Donald, Annie Britton, Juan P Casas, Tina Shah, Eric Brunner, Nicholas J Timpson, Julian P J Halcox, Michelle A Miller, Steve E Humphries, John Deanfield, Michael G Marmot, Aroon D Hingorani

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Abstract

C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis. Evidence in support of this link being causal would include an association robust to adjustments for confounders (multivariable standard regression analysis) and the association of CRP gene polymorphisms with atherosclerosis (Mendelian randomization analysis).
Original languageEnglish
Pages (from-to)e3013
JournalPLoS ONE
Volume3
Issue number8
DOIs
Publication statusPublished - 2008

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