Does high C-reactive protein concentration increase atherosclerosis?: The Whitehall II Study

Mika Kivimäki; Debbie A Lawlor; George Davey Smith; Meena Kumari; Ann Donald; Annie Britton; Juan P Casas; Tina Shah; Eric Brunner; Nicholas J Timpson; Julian P J Halcox; Michelle A Miller; Steve E Humphries; John Deanfield; Michael G Marmot; Aroon D Hingorani

doi:10.1371/journal.pone.0003013

Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study

Mika Kivimäki, Debbie A Lawlor, George Davey Smith, Meena Kumari, Ann Donald, Annie Britton, Juan P Casas, Tina Shah, Eric Brunner, Nicholas J Timpson, Julian P J Halcox, Michelle A Miller, Steve E Humphries, John Deanfield, Michael G Marmot, Aroon D Hingorani

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis. Evidence in support of this link being causal would include an association robust to adjustments for confounders (multivariable standard regression analysis) and the association of CRP gene polymorphisms with atherosclerosis (Mendelian randomization analysis).

Original language	English
Pages (from-to)	e3013
Journal	PLOS ONE
Volume	3
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0003013
Publication status	Published - 2008

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Kivimäki, M., Lawlor, D. A., Smith, G. D., Kumari, M., Donald, A., Britton, A., Casas, J. P., Shah, T., Brunner, E., Timpson, N. J., Halcox, J. P. J., Miller, M. A., Humphries, S. E., Deanfield, J., Marmot, M. G., & Hingorani, A. D. (2008). Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study. PLOS ONE, 3(8), e3013. https://doi.org/10.1371/journal.pone.0003013

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title = "Does high C-reactive protein concentration increase atherosclerosis?: The Whitehall II Study",

abstract = "C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis. Evidence in support of this link being causal would include an association robust to adjustments for confounders (multivariable standard regression analysis) and the association of CRP gene polymorphisms with atherosclerosis (Mendelian randomization analysis).",

author = "Mika Kivim{\"a}ki and Lawlor, \{Debbie A\} and Smith, \{George Davey\} and Meena Kumari and Ann Donald and Annie Britton and Casas, \{Juan P\} and Tina Shah and Eric Brunner and Timpson, \{Nicholas J\} and Halcox, \{Julian P J\} and Miller, \{Michelle A\} and Humphries, \{Steve E\} and John Deanfield and Marmot, \{Michael G\} and Hingorani, \{Aroon D\}",

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doi = "10.1371/journal.pone.0003013",

language = "English",

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pages = "e3013",

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Kivimäki, M, Lawlor, DA , Smith, GD, Kumari, M, Donald, A, Britton, A, Casas, JP, Shah, T, Brunner, E, Timpson, NJ, Halcox, JPJ, Miller, MA, Humphries, SE, Deanfield, J, Marmot, MG & Hingorani, AD 2008, 'Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study', PLOS ONE, vol. 3, no. 8, pp. e3013. https://doi.org/10.1371/journal.pone.0003013

TY - JOUR

T1 - Does high C-reactive protein concentration increase atherosclerosis?

T2 - The Whitehall II Study

AU - Kivimäki, Mika

AU - Lawlor, Debbie A

AU - Smith, George Davey

AU - Kumari, Meena

AU - Donald, Ann

AU - Britton, Annie

AU - Casas, Juan P

AU - Shah, Tina

AU - Brunner, Eric

AU - Timpson, Nicholas J

AU - Halcox, Julian P J

AU - Miller, Michelle A

AU - Humphries, Steve E

AU - Deanfield, John

AU - Marmot, Michael G

AU - Hingorani, Aroon D

PY - 2008

Y1 - 2008

N2 - C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis. Evidence in support of this link being causal would include an association robust to adjustments for confounders (multivariable standard regression analysis) and the association of CRP gene polymorphisms with atherosclerosis (Mendelian randomization analysis).

AB - C-reactive protein (CRP), a marker of systemic inflammation, is associated with risk of coronary events and sub-clinical measures of atherosclerosis. Evidence in support of this link being causal would include an association robust to adjustments for confounders (multivariable standard regression analysis) and the association of CRP gene polymorphisms with atherosclerosis (Mendelian randomization analysis).

U2 - 10.1371/journal.pone.0003013

DO - 10.1371/journal.pone.0003013

M3 - Article (Academic Journal)

C2 - 18714381

SN - 1932-6203

VL - 3

SP - e3013

JO - PLOS ONE

JF - PLOS ONE

IS - 8

ER -

Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study

Abstract

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