Dopamine and food reward: Effects of acute tyrosine/phenylalanine depletion on appetite

Charlotte A Hardman, Vanessa M B Herbert, Jeffrey M Brunstrom, Marcus R Munafò, Peter J Rogers

Research output: Contribution to journalArticle (Academic Journal)peer-review

26 Citations (Scopus)

Abstract

It has been suggested that obese individuals over-eat in order to compensate for deficits in the dopaminergic reward system. The current study used acute tyrosine/phenylalanine depletion (ATPD) to investigate the effect of reduced dopamine function on appetite and the reward value of food in healthy volunteers. The compensatory-eating hypothesis would predict an increase in the reward value and consumption of food following depletion by this method. In a double-blind, counterbalanced, crossover study, 17 male participants (mean age=29.2 (SEM=2.7) years; mean body mass index=24.4 (SEM=0.6) kg/m(2)) were administered with a tyrosine/phenylalanine-free mixture (TYR/PHE-free; depletion condition) and a balanced amino acid mixture (BAL; control). Plasma amino acid levels were measured at baseline and peak depletion (300min). Appetite, willingness to pay for food, liking, desired portion size and ad libitum food intake were also assessed. The TYR/PHE-free mixture was associated with significant decreases in tyrosine, phenylalanine, and the ratio of tyrosine+phenylalanine to the other large neutral amino acids (all p
Translated title of the contributionDopamine and food reward: Effects of acute tyrosine/phenylalanine depletion on appetite
Original languageEnglish
Pages (from-to)1202 - 1207
Number of pages6
JournalPhysiology and Behavior
Volume105
Issue number5
DOIs
Publication statusPublished - Mar 2012

Bibliographical note

Copyright © 2012 Elsevier Inc. All rights reserved.

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol
  • Nutrition and Behaviour

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