Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain

O'Keeffe Grainne, Barker Roger A, MA Caldwell

Research output: Contribution to journalArticle (Academic Journal)peer-review

78 Citations (Scopus)

Abstract

Dopaminergic receptors are expressed on neural precursor cells (NPCs) in the subventricular zone (SVZ) and are known to regulate NPC proliferation and differentiation fate in this region. We now report that this optimally requires the simultaneous activation of both D1-like and D2-like dopaminergic receptors with the agonists Bromocriptine, SKF-38393 and 7-OH-pipat maleate (BSP) in vitro. This is consistent with our previous findings that dopamine stimulates NPC proliferation through an EGF paracrine mechanism within the SVZ. Furthermore this combined dopamine agonist therapy rescues NPC proliferation in the SVZ in the 6-OHDA animal model of PD and importantly significantly increases neuronal differentiation in the olfactory bulb to a greater extent than we showed previously with levodopa. This result has implications for the use of dopaminergic therapies in PD and in the development of such therapies focusing on upregulating SVZ neurogenesis.
Translated title of the contributionDopaminergic modulation of neurogenesis in the subventricular zone of the adult brain
Original languageEnglish
Pages (from-to)2888 - 2894
Number of pages7
JournalCell Cycle
Volume8
Publication statusPublished - Sep 2009

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