Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Shiv Kumar, Rakesh K. Saunthwal, Kapil M. Saini, Akhilesh K. Verma*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

Original languageEnglish
Pages (from-to)10721-10724
Number of pages4
JournalChemical Communications
Volume55
Issue number72
Early online date12 Aug 2019
DOIs
Publication statusE-pub ahead of print - 12 Aug 2019

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