Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Shiv Kumar; Rakesh K. Saunthwal; Kapil M. Saini; Akhilesh K. Verma

doi:10.1039/c9cc04746h

Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Shiv Kumar, Rakesh K. Saunthwal, Kapil M. Saini, Akhilesh K. Verma^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Abstract

An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

Original language	English
Pages (from-to)	10721-10724
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	72
Early online date	12 Aug 2019
DOIs	https://doi.org/10.1039/c9cc04746h
Publication status	E-pub ahead of print - 12 Aug 2019

Access to Document

10.1039/c9cc04746h

Handle.net

Persistent link

Cite this

@article{026c0b3467ea44c783f528bc07f7fe92,

title = "Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles",

abstract = "An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.",

author = "Shiv Kumar and Saunthwal, {Rakesh K.} and Saini, {Kapil M.} and Verma, {Akhilesh K.}",

year = "2019",

month = aug,

day = "12",

doi = "10.1039/c9cc04746h",

language = "English",

volume = "55",

pages = "10721--10724",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "72",

}

TY - JOUR

T1 - Dual function of carbon tetrachloride

T2 - Synthesis of chlorinated heterocycles

AU - Kumar, Shiv

AU - Saunthwal, Rakesh K.

AU - Saini, Kapil M.

AU - Verma, Akhilesh K.

PY - 2019/8/12

Y1 - 2019/8/12

N2 - An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

AB - An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

UR - http://www.scopus.com/inward/record.url?scp=85071788592&partnerID=8YFLogxK

U2 - 10.1039/c9cc04746h

DO - 10.1039/c9cc04746h

M3 - Article (Academic Journal)

C2 - 31429428

AN - SCOPUS:85071788592

SN - 1359-7345

VL - 55

SP - 10721

EP - 10724

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Abstract

Access to Document

Handle.net

Other files and links

Fingerprint

Cite this