Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Shiv Kumar; Rakesh K. Saunthwal; Kapil M. Saini; Akhilesh K. Verma

doi:10.1039/c9cc04746h

Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Shiv Kumar
, Rakesh K. Saunthwal
, Kapil M. Saini
, Akhilesh K. Verma^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Abstract

An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

Original language	English
Pages (from-to)	10721-10724
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	72
Early online date	12 Aug 2019
DOIs	https://doi.org/10.1039/c9cc04746h
Publication status	E-pub ahead of print - 12 Aug 2019

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title = "Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles",

abstract = "An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.",

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T1 - Dual function of carbon tetrachloride

T2 - Synthesis of chlorinated heterocycles

AU - Kumar, Shiv

AU - Saunthwal, Rakesh K.

AU - Saini, Kapil M.

AU - Verma, Akhilesh K.

PY - 2019/8/12

Y1 - 2019/8/12

N2 - An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

AB - An efficient tandem approach to invent highly chlorinated and structurally diversified dihydropyridine fused heterocycles from easily accessible ortho-alkynylaldehydes and primary amines under metal-free conditions via four sequential bond formations is described. The proposed tandem route proceeds via a carbon tetrachloride-mediated 6-endo-dig ring closure followed by nucleophilic attack of the trichloromethyl anion.

UR - https://www.scopus.com/pages/publications/85071788592

U2 - 10.1039/c9cc04746h

DO - 10.1039/c9cc04746h

M3 - Article (Academic Journal)

C2 - 31429428

AN - SCOPUS:85071788592

SN - 1359-7345

VL - 55

SP - 10721

EP - 10724

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Dual function of carbon tetrachloride: Synthesis of chlorinated heterocycles

Abstract

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