DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort

Benjamin G Faber; Denis Baird; Celia L Gregson; Jenny S Gregory; Rebecca J Barr; Richard M Aspden; J. Lynch; Michael C Nevitt; Nancy E Lane; Eric Orwoll; Jonathan H Tobias; Osteoporotic Fractures in Men (MrOS) Study Research Group

doi:10.1016/j.joca.2017.09.006

DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort

Benjamin G Faber, Denis Baird, Celia L Gregson, Jenny S Gregory, Rebecca J Barr, Richard M Aspden, J. Lynch, Michael C Nevitt, Nancy E Lane, Eric Orwoll, Jonathan H Tobias, Osteoporotic Fractures in Men (MrOS) Study Research Group

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Abstract

OBJECTIVE: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.

METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).

RESULTS: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].

CONCLUSIONS: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.

Original language	English
Pages (from-to)	2031-2038
Number of pages	8
Journal	Osteoarthritis and Cartilage
Volume	25
Issue number	12
Early online date	21 Sept 2017
DOIs	https://doi.org/10.1016/j.joca.2017.09.006
Publication status	Published - Dec 2017

Keywords

Hip shape
Joint shape
Active shape modeling

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Faber, B. G., Baird, D., Gregson, C. L., Gregory, J. S., Barr, R. J., Aspden, R. M., Lynch, J., Nevitt, M. C., Lane, N. E., Orwoll, E., Tobias, J. H., & Osteoporotic Fractures in Men (MrOS) Study Research Group (2017). DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort. Osteoarthritis and Cartilage, 25(12), 2031-2038. https://doi.org/10.1016/j.joca.2017.09.006

@article{09eada748ccc4993bd603a9e3b44cd13,

title = "DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort",

abstract = "OBJECTIVE: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).RESULTS: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].CONCLUSIONS: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.",

keywords = "Hip shape, Joint shape, Active shape modeling",

author = "Faber, {Benjamin G} and Denis Baird and Gregson, {Celia L} and Gregory, {Jenny S} and Barr, {Rebecca J} and Aspden, {Richard M} and J. Lynch and Nevitt, {Michael C} and Lane, {Nancy E} and Eric Orwoll and Tobias, {Jonathan H} and {Osteoporotic Fractures in Men (MrOS) Study Research Group}",

year = "2017",

month = dec,

doi = "10.1016/j.joca.2017.09.006",

language = "English",

volume = "25",

pages = "2031--2038",

journal = "Osteoarthritis and Cartilage",

issn = "1063-4584",

publisher = "W.B. Saunders",

number = "12",

}

Faber, BG, Baird, D, Gregson, CL, Gregory, JS, Barr, RJ, Aspden, RM, Lynch, J, Nevitt, MC, Lane, NE, Orwoll, E, Tobias, JH & Osteoporotic Fractures in Men (MrOS) Study Research Group 2017, 'DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort', Osteoarthritis and Cartilage, vol. 25, no. 12, pp. 2031-2038. https://doi.org/10.1016/j.joca.2017.09.006

TY - JOUR

T1 - DXA-derived hip shape is related to osteoarthritis

T2 - findings from in the MrOS cohort

AU - Faber, Benjamin G

AU - Baird, Denis

AU - Gregson, Celia L

AU - Gregory, Jenny S

AU - Barr, Rebecca J

AU - Aspden, Richard M

AU - Lynch, J.

AU - Nevitt, Michael C

AU - Lane, Nancy E

AU - Orwoll, Eric

AU - Tobias, Jonathan H

AU - Osteoporotic Fractures in Men (MrOS) Study Research Group

PY - 2017/12

Y1 - 2017/12

N2 - OBJECTIVE: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).RESULTS: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].CONCLUSIONS: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.

AB - OBJECTIVE: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort.METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study. Associations between the top ten HSMs, and prevalent RHOA from pelvic radiographs obtained 4.6 years later, were analysed in 4100 participants. RHOA was defined as Croft score ≥ 2. Hip pain was based on pain on walking, hip pain on examination, and Western Ontario and McMaster Universities Arthritis Index (WOMAC).RESULTS: The five HSMs associated with RHOA showed features of either pincer- or cam-type deformities. HSM 1 (increased pincer-type deformity) was positively associated with RHOA [1.23 (1.09,1.39)] [odds ratio and 95% CI]. HSM 8 (reduced pincer-type deformity) was inversely associated with RHOA [0.79 (0.70,0.89)]. HSM 10 (increased cam-type deformity) was positively associated with RHOA [1.21 (1.07,1.37)]. HSM 3 and HSM 4 (reduced cam-type deformity) were inversely associated with RHOA [0.73 (0.65,0.83) and 0.82 (0.73,0.93) respectively]. HSM 3 was inversely related to pain on examination [0.84 (0.76,0.92)] and walking [0.88, (0.81,0.95)], and to WOMAC score [0.87 (0.80,0.93)].CONCLUSIONS: DXA-derived measures of hip shape are associated with RHOA, and to a lesser extent hip pain, possibly reflecting their role in the pathogenesis of hip OA.

KW - Hip shape

KW - Joint shape

KW - Active shape modeling

U2 - 10.1016/j.joca.2017.09.006

DO - 10.1016/j.joca.2017.09.006

M3 - Article (Academic Journal)

C2 - 28942368

SN - 1063-4584

VL - 25

SP - 2031

EP - 2038

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 12

ER -

DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort

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