Dynamic causal modelling of seizure activity in a rat model

Margarita Papadopoulou, Gerald Cooray, Richard Rosch, Rosalyn Moran, Daniele Marinazzo, Karl Friston

Research output: Contribution to journalArticle (Academic Journal)peer-review

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This paper presents a physiological account of seizure activity and its evolution over time using a rat model of induced epilepsy. We analyse spectral activity recorded in the hippocampi of three rats who received kainic acid injections in the right hippocampus .We use dynamic causal modelling of seizure activity and Bayesian model reduction to identify the key synaptic and activity parameters that underlie seizure onset. Using recent advances in hierarchical modelling (parametric empirical Bayes), we characterise seizure onset in terms of slow fluctuations in synaptic excitability of specific neuronal populations. Our results suggest differences in the pathophysiology of seizure activity in the lesioned versus the non-lesioned hippocampus – with larger changes in inhibition, excitation and temporal summation on the lesioned side.
Original languageEnglish
Pages (from-to)518-532
Number of pages15
Early online date14 Sep 2016
Publication statusPublished - 1 Feb 2017

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