Dynamic foldamer chemistry

Bryden A F Le Bailly, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)
364 Downloads (Pure)


Foldamers can be made more than pieces of static, conformationally uniform molecular architecture by designing into their structure the conformational dynamism characteristic of functional molecular machines. We show that these dynamic foldamers display biomimetic properties reminiscent of allosteric proteins and receptor molecules. They can translate chemical signals into conformational changes, and hence into chemical outputs such as control of reactivity and selectivity. Future developments could see dynamic foldamers operating in the membrane phase providing artificial mechanisms for communication and control that integrate synthetic chemistry into synthetic biology.
Original languageEnglish
Pages (from-to)4852-4863
Number of pages12
JournalChemical Communications
Issue number27
Early online date2 Mar 2016
Publication statusPublished - 7 Apr 2016

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