Abstract
The sexually transmitted infection (STI) Herpes simplex virus type-2 (HSV-2) is of public health concern because it is a very common frequently unrecognized lifelong infection, which may facilitate HIV transmission. Within HIV/STI modeling, structural uncertainty has received less attention than parametric uncertainty. By merging the compartments of a "complex" model, a "simple" HSV-2 model is developed. Sexual interactions between female sex workers (FSWs) and clients are modeled using data from India. Latin Hypercube Sampling selects from parameter distributions and both models are run for each of the 10,000 parameter sets generated. Outputs are compared (except for 2,450 unrealistic simulations). The simple model is a good approximation to the complex model once the HSV-2 epidemic has reached 60% of the equilibrium prevalence (95% of the 7,550 runs produced
| Original language | English |
|---|---|
| Pages (from-to) | 720-49 |
| Number of pages | 30 |
| Journal | Bulletin of Mathematical Biology |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 2009 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Research Groups and Themes
- GEM-B
Keywords
- Computer Simulation
- Female
- Herpes Genitalis
- Herpesvirus 2, Human
- Humans
- India
- Male
- Models, Biological
- Models, Statistical
Fingerprint
Dive into the research topics of 'Dynamic modeling of herpes simplex virus type-2 (HSV-2) transmission: issues in structural uncertainty'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver