Dynamic regulation of glucocorticoid signalling in health and disease

Research output: Contribution to journalArticle (Academic Journal)peer-review

82 Citations (Scopus)

Abstract

Activation of the glucocorticoid receptor (GR) by endogenous and synthetic glucocorticoids regulates hundreds of genes to control regulatory networks in development, metabolism, cognition and inflammation. Elucidation of the mechanisms that regulate glucocorticoid action has highlighted the dynamic nature of hormone signalling and provides novel insights into genomic glucocorticoid actions. The major factors that regulate GR function include chromatin structure, epigenetics, genetic variation and the pattern of glucocorticoid hormone secretion. We review our current understanding of the mechanisms that contribute to GR signalling and how these contribute to glucocorticoid sensitivity, resistance and side effects.
Translated title of the contributionDynamic regulation of glucocorticoid signalling in health and disease
Original languageEnglish
Pages (from-to)403 - 412
Number of pages10
JournalRheumatology
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 2012

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