Dynamic responses of the adrenal steroidogenic regulatory network

Francesca Spiga, Eder Zavala, Jamie Walker, Zidong Zhao, John Terry, Stafford Lightman

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)
213 Downloads (Pure)

Abstract

Our ability to respond to stress depends on a remarkably dynamic process of hormone secretion. The rapid release of glucocorticoid hormones from the adrenal glands is critical to mount such an efficient response to stress, particularly during inflammation. Although many key factors involved in this process have been studied, the way in which these factors interact dynamically with one another to regulate glucocorticoid secretion has not been investigated. Here, we develop a mathematical model of the regulatory network controlling glucocorticoid synthesis and, by combining this with in vivo experiments, show how this network governs changes in adrenal responsiveness under basal unstressed physiological conditions and under exposure to inflammatory stress.
Original languageEnglish
Pages (from-to)E6466-E6474
Number of pages9
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number31
Early online date17 Jul 2017
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • adrenal gland
  • glucocorticoids
  • steroidogenesis
  • stress response
  • mathematical modeling

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