Dynamics of adrenal glucocorticoid steroidogenesis in health and disease

Research output: Contribution to journalReview article (Academic Journal)peer-review

30 Citations (Scopus)

Abstract

The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the origin of the glucocorticoid ultradian rhythm. Our recent research shows that the ultradian rhythm of glucocorticoids depends on highly dynamic processes within adrenocortical steroidogenic cells. Furthermore, we have evidence that disruption of these dynamics leads to abnormal glucocorticoid secretion observed in disease and critical illness in both humans and rats.

Original languageEnglish
Pages (from-to)227-34
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume408
DOIs
Publication statusPublished - 15 Jun 2015

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