TY - JOUR
T1 - Dynamics of adrenal glucocorticoid steroidogenesis in health and disease
AU - Spiga, Francesca
AU - Lightman, Stafford L
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/6/15
Y1 - 2015/6/15
N2 - The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the origin of the glucocorticoid ultradian rhythm. Our recent research shows that the ultradian rhythm of glucocorticoids depends on highly dynamic processes within adrenocortical steroidogenic cells. Furthermore, we have evidence that disruption of these dynamics leads to abnormal glucocorticoid secretion observed in disease and critical illness in both humans and rats.
AB - The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the origin of the glucocorticoid ultradian rhythm. Our recent research shows that the ultradian rhythm of glucocorticoids depends on highly dynamic processes within adrenocortical steroidogenic cells. Furthermore, we have evidence that disruption of these dynamics leads to abnormal glucocorticoid secretion observed in disease and critical illness in both humans and rats.
U2 - 10.1016/j.mce.2015.02.005
DO - 10.1016/j.mce.2015.02.005
M3 - Review article (Academic Journal)
C2 - 25662280
SN - 0303-7207
VL - 408
SP - 227
EP - 234
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
ER -