Dysfunctional HDL takes its Toll on the endothelial glycocalyx

Matthew J. Butler*

*Corresponding author for this work

Research output: Contribution to journalComment/debate (Academic Journal)peer-review

1 Citation (Scopus)


Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link between renal failure and cardiovascular disease.

Original languageEnglish
Pages (from-to)450-452
Number of pages3
JournalKidney International
Issue number3
Early online date19 Feb 2020
Publication statusPublished - Mar 2020


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