Dysfunctional HDL takes its Toll on the endothelial glycocalyx

Matthew J. Butler

doi:10.1016/j.kint.2019.11.017

Dysfunctional HDL takes its Toll on the endothelial glycocalyx

Matthew J. Butler^*

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link between renal failure and cardiovascular disease.

Original language	English
Pages (from-to)	450-452
Number of pages	3
Journal	Kidney International
Volume	97
Issue number	3
Early online date	19 Feb 2020
DOIs	https://doi.org/10.1016/j.kint.2019.11.017
Publication status	Published - Mar 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.kint.2019.11.017

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title = "Dysfunctional HDL takes its Toll on the endothelial glycocalyx",

abstract = "Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link between renal failure and cardiovascular disease.",

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N2 - Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link between renal failure and cardiovascular disease.

AB - Patients with end-stage renal disease have a high risk of dying from cardiovascular disease that cannot be explained solely by traditional cardiovascular disease risk factors. Hesse et al. suggest that dysfunctional high-density lipoprotein cholesterol generated in patients with end-stage renal disease causes endothelial glycocalyx degradation. Glycocalyx degradation may represent one of the earliest insults leading to atheroma formation, and so this work suggests a novel link between renal failure and cardiovascular disease.

UR - https://www.scopus.com/pages/publications/85079147356

U2 - 10.1016/j.kint.2019.11.017

DO - 10.1016/j.kint.2019.11.017

M3 - Comment/debate (Academic Journal)

C2 - 32087885

AN - SCOPUS:85079147356

SN - 0085-2538

VL - 97

SP - 450

EP - 452

JO - Kidney International

JF - Kidney International

IS - 3

ER -

Dysfunctional HDL takes its Toll on the endothelial glycocalyx

Abstract

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