TY - JOUR
T1 - Early changes in fatigue and cytokine concentration following etanercept treatment in rheumatoid arthritis
AU - Mercieca, Cecilia
AU - Zakout, Samy
AU - Kirwan, John
AU - Sharif, Mohammed
AU - Smith, Elaine
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Aim: To study early changes in fatigue, disease activity and cytokines within individual patients with rheumatoid arthritis (RA) following etanercept treatment. Methods: 12-week prospective observational study of 21 RA patients starting etanercept therapy. DAS28, fatigue, IL-1β, IL-4, IL-6, IL-8 and IL-1ra were measured. Results: DAS28, fatigue and IL-6 improved significantly by 40% compared with baseline values in the first 4 weeks (P < 0.05), but followed different time courses. The main improvement in IL-6 occurred by week 2, fatigue (BRAF MDQ) by week 3 and DAS28 by week 4. At week 3 improvement of DAS28 (24%) was significantly less than BRAF MDQ (42%, P < 0.003) and IL-6 (43%, P < 0.03). Conclusion: Fatigue improved faster than disease activity, suggesting that fatigue may be mediated via a different pathway.
AB - Aim: To study early changes in fatigue, disease activity and cytokines within individual patients with rheumatoid arthritis (RA) following etanercept treatment. Methods: 12-week prospective observational study of 21 RA patients starting etanercept therapy. DAS28, fatigue, IL-1β, IL-4, IL-6, IL-8 and IL-1ra were measured. Results: DAS28, fatigue and IL-6 improved significantly by 40% compared with baseline values in the first 4 weeks (P < 0.05), but followed different time courses. The main improvement in IL-6 occurred by week 2, fatigue (BRAF MDQ) by week 3 and DAS28 by week 4. At week 3 improvement of DAS28 (24%) was significantly less than BRAF MDQ (42%, P < 0.003) and IL-6 (43%, P < 0.03). Conclusion: Fatigue improved faster than disease activity, suggesting that fatigue may be mediated via a different pathway.
KW - biologic therapies
KW - cytokines
KW - fatigue
KW - IL-6
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=84928620761&partnerID=8YFLogxK
U2 - 10.2217/ijr.15.4
DO - 10.2217/ijr.15.4
M3 - Article (Academic Journal)
AN - SCOPUS:84928620761
SN - 1758-4272
VL - 10
SP - 79
EP - 84
JO - International Journal of Clinical Rheumatology
JF - International Journal of Clinical Rheumatology
IS - 2
ER -