Early immature neuronal death is partially involved in memory impairment induced by cerebral ischemia

Jee Hyun Yi, So Yeon Cho, Se Jin Jeon, Ji Wook Jung, Man Seok Park, Dong Hyun Kim, Jong Hoon Ryu

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Abstract

Memory impairment is a common after an ischemic stroke. While delayed neuronal death in the CA1 region is usually linked to cerebral ischemia-induced memory impairment, the role of early immature neuronal death within the DG region in the memory state of an ischemic stroke model has rarely been studied. Here, we show a partial role of immature neuronal death in memory impairment in a global ischemia model. We found early immature neuronal death, which was determined by DCX and NeuN-double-staining. Injection of z-DEVD-fmk, a caspase-3 inhibitor, into the DG region rescued cells from immature neuronal death in the DG region without affecting delayed neuronal death in the CA1 region of an ischemic brain. Moreover, z-DEVD-fmk treatment partially rescued ischemia-induced spatial memory impairment. We also found that ischemia-induced LTP impairment in the perforant pathway was restored by z-DEVD-fmk treatment. These results suggest that early immature neuronal death is partially involved in ischemia-induced spatial memory impairment.
Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalBehavioural Brain Research
Volume308
Early online date13 Apr 2016
DOIs
Publication statusPublished - 15 Jul 2016

Keywords

  • Ischemia
  • immature neuron
  • spatial memory
  • long-term potentiation

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