Memory impairment is a common after an ischemic stroke. While delayed neuronal death in the CA1 region is usually linked to cerebral ischemia-induced memory impairment, the role of early immature neuronal death within the DG region in the memory state of an ischemic stroke model has rarely been studied. Here, we show a partial role of immature neuronal death in memory impairment in a global ischemia model. We found early immature neuronal death, which was determined by DCX and NeuN-double-staining. Injection of z-DEVD-fmk, a caspase-3 inhibitor, into the DG region rescued cells from immature neuronal death in the DG region without affecting delayed neuronal death in the CA1 region of an ischemic brain. Moreover, z-DEVD-fmk treatment partially rescued ischemia-induced spatial memory impairment. We also found that ischemia-induced LTP impairment in the perforant pathway was restored by z-DEVD-fmk treatment. These results suggest that early immature neuronal death is partially involved in ischemia-induced spatial memory impairment.
- immature neuron
- spatial memory
- long-term potentiation
Yi, J. H., Cho, S. Y., Jeon, S. J., Jung, J. W., Park, M. S., Kim, D. H., & Ryu, J. H. (2016). Early immature neuronal death is partially involved in memory impairment induced by cerebral ischemia. Behavioural Brain Research, 308, 75-82. https://doi.org/10.1016/j.bbr.2016.04.019