Effect of baroreceptor stimulation on the respiratory pattern: insights into respiratory-sympathetic interactions

D M Baekey, Y I Molkov, JFR Paton, I A Rybak, T E Dick

Research output: Contribution to journalArticle (Academic Journal)peer-review

61 Citations (Scopus)

Abstract

Sympathetic nerve activity (SNA) is modulated by respiratory activity which indicates the existence of direct interactions between the respiratory and sympathetic networks within the brainstem. Our experimental studies reveal that T(E) prolongation evoked by baroreceptor stimulation varies with respiratory phase and depends on the pons. We speculate that the sympathetic baroreceptor reflex, providing negative feedback from baroreceptors to the rostral ventrolateral medulla and SNA, has two pathways: one direct and independent of the respiratory-sympathetic interactions and the other operating via the respiratory pattern generator and is hence dependent on the respiratory modulation of SNA. Our experimental studies in the perfused in situ rat preparation and complementary computational modelling studies support the hypothesis that baroreceptor activation during expiration prolongs the T(E) via transient activation of post-inspiratory and inhibition of augmenting expiratory neurones of the Bötzinger Complex (BötC). We propose that these BötC neurones are also involved in the respiratory modulation of SNA, and contribute to the respiratory modulation of the sympathetic baroreceptor reflex.
Translated title of the contributionEffect of baroreceptor stimulation on the respiratory pattern: insights into respiratory-sympathetic interactions
Original languageEnglish
Pages (from-to)135 - 145
Number of pages10
JournalRespiratory Physiology and Neurobiology
Volume174
DOIs
Publication statusPublished - Nov 2010

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