Effect of decellularization protocol of human saphenous veins on cytotoxicity and matrix component

Rationale for the study: It is proposed that development of arterial-like vascular conduits using decellularised venous extracellular matrix scaffolds seeded with cells are desirable to overcome the problem of early vein graft thrombosis, late vein graft thickening, and artificial grafts infection of autologous, xeno- and artificial graft conduit used for coronary artery bypass surgery. The aim of this study was to compare the effect of different decellularisation protocols on vein matrix components and cytotoxicity on seeded cells.