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Abstract
Background: Early-term-born subjects, (37–38 weeks’ gestation), form a large
part of the population and have an increased risk of neonatal respiratory morbidity and childhood respiratory symptoms; there is a paucity of data on their later lung function. We sought to (1) compare lung function at 8–9 and 14–17 years in early-term-born children with full-term-born children (39–43 weeks’ gestation); (2) assess the role of caesarean section delivery; and (3) compare respiratory symptoms and diagnosis of asthma.
Methods: Caucasian, singleton, term births from the Avon Longitudinal Study of Parents and Children (n=14,062) who had lung spirometry at 8–9 (n¼5,465) and/or 14–17 (n=3,666) years were classified as early or full term.
Results: At 8–9 years, standardized spirometry measures, although within the normal range, were lower in the early-term-born group, (n=911), compared to full-term controls (n=4,554). Delivery by caesarean section did not influence later spirometry, and the effect of early-term birth was not modified by delivery by caesarean section. At 14–17 years, the spirometry measures in the early-term group, (n=602), were similar to the full-term group (3,064), and the rates of asthma and respiratory symptoms were also similar between the two gestation groups.
Conclusions: Early-term-born children had lower lung function values at 8–9 years compared to the full-term group, but were similar by 14–17 years of age. Delivery at early term should be avoided due to early and late morbidity.
part of the population and have an increased risk of neonatal respiratory morbidity and childhood respiratory symptoms; there is a paucity of data on their later lung function. We sought to (1) compare lung function at 8–9 and 14–17 years in early-term-born children with full-term-born children (39–43 weeks’ gestation); (2) assess the role of caesarean section delivery; and (3) compare respiratory symptoms and diagnosis of asthma.
Methods: Caucasian, singleton, term births from the Avon Longitudinal Study of Parents and Children (n=14,062) who had lung spirometry at 8–9 (n¼5,465) and/or 14–17 (n=3,666) years were classified as early or full term.
Results: At 8–9 years, standardized spirometry measures, although within the normal range, were lower in the early-term-born group, (n=911), compared to full-term controls (n=4,554). Delivery by caesarean section did not influence later spirometry, and the effect of early-term birth was not modified by delivery by caesarean section. At 14–17 years, the spirometry measures in the early-term group, (n=602), were similar to the full-term group (3,064), and the rates of asthma and respiratory symptoms were also similar between the two gestation groups.
Conclusions: Early-term-born children had lower lung function values at 8–9 years compared to the full-term group, but were similar by 14–17 years of age. Delivery at early term should be avoided due to early and late morbidity.
Original language | English |
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Pages (from-to) | 1212-1221 |
Number of pages | 10 |
Journal | Pediatric Pulmonology |
Volume | 51 |
Issue number | 11 |
Early online date | 28 Apr 2016 |
DOIs | |
Publication status | Published - Nov 2016 |
Keywords
- Avon Longitudinal Study of Parents and Children (ALSPAC)
- lung physiology
- pulmonary function tests
- cohort study
- asthma
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THE NATURAL HISTORY OF ASTHMA AND WHEEZING ILLNESSES FROM BIRTH TO ADOLESCENCE: DETERMINANTS OF THE REMISSION OF ASTHMA
Henderson, A. J. W. (Principal Investigator)
1/10/06 → 1/10/10
Project: Research