Skip to content

Effect of group-based outpatient physiotherapy on function after total knee replacement: The ARENA randomised controlled trial

Research output: Contribution to journalArticle

Original languageEnglish
JournalArthritis Care and Research
DateAccepted/In press - 17 Apr 2019
DatePublished (current) - 29 Apr 2019


ObjectiveTo evaluate the long‐term clinical effectiveness of a novel group‐based outpatient physiotherapy following total knee replacement (TKR).
MethodsIn this two centre, unblinded, superiority, randomised controlled trial, 180 patients on a waiting list for primary TKR due to osteoarthritis were randomised to a 6 session group‐based outpatient physiotherapy intervention and usual care (n=89) or usual care alone (n=91).The primary outcome was patient‐reported functional ability measured by the Lower Extremity Functional Scale at 12 months post‐operative. Secondary outcomes included knee symptoms, depression, anxiety and satisfaction. Questionnaires were completed pre‐operatively and 3, 6 and 12 months post‐operatively.
ResultsThe mean difference in function between groups was 4.47 (95% CI 0.20 to 8.75; p=0.04) at 12 months post‐operative, favouring the intervention.. The mean difference in function between groups decreased over time; from 8.1 points at 3 months (95% CI 3.8 to 12.4; p<0.001) to 5.4 (95% CI 1.1 to 9.8; p=0.015) at 6 months post‐operative. There were no clinically relevant differences in any secondary outcomes between groups, although patients in the intervention group were more likely to be satisfied with their physiotherapy. No serious adverse events related to the intervention were reported.
ConclusionSupplementing usual care with this group‐based outpatient physiotherapy intervention led to improvements in function at 12 months after TKR, although the magnitude of the difference was below the minimal clinically important different of 9 points. However, patient satisfaction was higher in the intervention group and there was some evidence of clinically relevant improvements in function at 3 months.

    Structured keywords

  • Centre for Surgical Research

    Research areas

  • Knee replacement, physiotherapy, function, pain, satisfaction

Download statistics

No data available



  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 343 KB, PDF document

    Licence: CC BY


View research connections

Related faculties, schools or groups