Effect of heart transplantation on survival in ambulatory and decompensated heart failure

NR Banner, CA Rogers, RS Bonser

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)

Abstract

BACKGROUND: In the absence of randomized trials comparing heart transplantation (HTx) with medical therapy for the treatment of advanced heart failure (HF), the role of HTx remains uncertain. Using data from a national audit, we examined the effect of HTx on HF mortality in the United Kingdom. METHODS: Two thousand two hundred nineteen adults listed for HTx from April 1995 to October 2003 and followed to June 2007 were analyzed. In a substudy of 627 patients from two centers, ambulatory patients were risk-stratified by the heart failure survival score. A time-dependent nonproportional hazards model was used to estimate the effect of HTx. RESULTS: Fourteen percent of patients were nonambulatory at listing. Death while waiting was higher among nonambulatory patients (19% vs. 14% in the ambulatory group, P
Translated title of the contributionEffect of heart transplantation on survival in ambulatory and decompensated heart failure
Original languageEnglish
Pages (from-to)1515 - 1522
Number of pages8
JournalTransplantation
Volume86
Issue number11
DOIs
Publication statusPublished - 15 Dec 2008

Bibliographical note

Publisher: Wolters

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