Abstract
BACKGROUND: In the absence of randomized trials comparing heart transplantation (HTx) with medical therapy for the treatment of advanced heart failure (HF), the role of HTx remains uncertain. Using data from a national audit, we examined the effect of HTx on HF mortality in the United Kingdom. METHODS: Two thousand two hundred nineteen adults listed for HTx from April 1995 to October 2003 and followed to June 2007 were analyzed. In a substudy of 627 patients from two centers, ambulatory patients were risk-stratified by the heart failure survival score. A time-dependent nonproportional hazards model was used to estimate the effect of HTx. RESULTS: Fourteen percent of patients were nonambulatory at listing. Death while waiting was higher among nonambulatory patients (19% vs. 14% in the ambulatory group, P
| Translated title of the contribution | Effect of heart transplantation on survival in ambulatory and decompensated heart failure |
|---|---|
| Original language | English |
| Pages (from-to) | 1515 - 1522 |
| Number of pages | 8 |
| Journal | Transplantation |
| Volume | 86 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 15 Dec 2008 |