Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas

Nadeem Khan; Sriram Mupparaju; Shahryar K Hekmatyar; Huagang Hou; Jean P Lariviere; Eugene Demidenko; David J Gladstone; Risto A Kauppinen; Harold M Swartz

doi:10.1016/j.ijrobp.2010.05.045

Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas

Nadeem Khan
, Sriram Mupparaju
, Shahryar K Hekmatyar
, Huagang Hou
, Jean P Lariviere
, Eugene Demidenko
, David J Gladstone
, Risto A Kauppinen
, Harold M Swartz

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

Abstract

Lack of methods for repeated assessment of tumor pO(2) limits the ability to test and optimize hypoxia-modifying procedures being developed for clinical applications. We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy.

Original language	English
Pages (from-to)	1193-200
Number of pages	8
Journal	International Journal of Radiation Oncology - Biology - Physics
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/j.ijrobp.2010.05.045
Publication status	Published - 2010

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Khan, N., Mupparaju, S., Hekmatyar, S. K., Hou, H., Lariviere, J. P., Demidenko, E., Gladstone, D. J., Kauppinen, R. A., & Swartz, H. M. (2010). Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas. International Journal of Radiation Oncology - Biology - Physics, 78(4), 1193-200. https://doi.org/10.1016/j.ijrobp.2010.05.045

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title = "Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas",

abstract = "Lack of methods for repeated assessment of tumor pO(2) limits the ability to test and optimize hypoxia-modifying procedures being developed for clinical applications. We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy.",

author = "Nadeem Khan and Sriram Mupparaju and Hekmatyar, \{Shahryar K\} and Huagang Hou and Lariviere, \{Jean P\} and Eugene Demidenko and Gladstone, \{David J\} and Kauppinen, \{Risto A\} and Swartz, \{Harold M\}",

year = "2010",

doi = "10.1016/j.ijrobp.2010.05.045",

language = "English",

volume = "78",

pages = "1193--200",

journal = "International Journal of Radiation Oncology - Biology - Physics",

issn = "1879-355X",

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Khan, N, Mupparaju, S, Hekmatyar, SK, Hou, H, Lariviere, JP, Demidenko, E, Gladstone, DJ, Kauppinen, RA & Swartz, HM 2010, 'Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas', International Journal of Radiation Oncology - Biology - Physics, vol. 78, no. 4, pp. 1193-200. https://doi.org/10.1016/j.ijrobp.2010.05.045

TY - JOUR

T1 - Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas

AU - Khan, Nadeem

AU - Mupparaju, Sriram

AU - Hekmatyar, Shahryar K

AU - Hou, Huagang

AU - Lariviere, Jean P

AU - Demidenko, Eugene

AU - Gladstone, David J

AU - Kauppinen, Risto A

AU - Swartz, Harold M

PY - 2010

Y1 - 2010

N2 - Lack of methods for repeated assessment of tumor pO(2) limits the ability to test and optimize hypoxia-modifying procedures being developed for clinical applications. We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy.

AB - Lack of methods for repeated assessment of tumor pO(2) limits the ability to test and optimize hypoxia-modifying procedures being developed for clinical applications. We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy.

U2 - 10.1016/j.ijrobp.2010.05.045

DO - 10.1016/j.ijrobp.2010.05.045

M3 - Article (Academic Journal)

C2 - 20813466

SN - 1879-355X

VL - 78

SP - 1193

EP - 1200

JO - International Journal of Radiation Oncology - Biology - Physics

JF - International Journal of Radiation Oncology - Biology - Physics

IS - 4

ER -

Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas

Abstract

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