Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India

U S Deshmukh; C V Joglekar; H G Lubree; L V Ramdas; D S Bhat; S S Naik; P S Hardikar; D A Raut; T B Konde; A K Wills; A A Jackson; H Refsum; A S Nanivadekar; C H Fall; C S Yajnik

doi:10.1038/ejcn.2010.15

Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India

U S Deshmukh, C V Joglekar, H G Lubree, L V Ramdas, D S Bhat, S S Naik, P S Hardikar, D A Raut, T B Konde, A K Wills, A A Jackson, H Refsum, A S Nanivadekar, C H Fall, C S Yajnik

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

42 Citations (Scopus)

Abstract

Vitamin B(12) (B(12)) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B(12) and folic acid on plasma total homocysteine (tHcy) concentration.

Original language	English
Pages (from-to)	495-502
Number of pages	8
Journal	European Journal of Clinical Nutrition
Volume	64
Issue number	5
DOIs	https://doi.org/10.1038/ejcn.2010.15
Publication status	Published - 2010

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Deshmukh, U. S., Joglekar, C. V., Lubree, H. G., Ramdas, L. V., Bhat, D. S., Naik, S. S., Hardikar, P. S., Raut, D. A., Konde, T. B., Wills, A. K., Jackson, A. A., Refsum, H., Nanivadekar, A. S., Fall, C. H., & Yajnik, C. S. (2010). Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India. European Journal of Clinical Nutrition, 64(5), 495-502. https://doi.org/10.1038/ejcn.2010.15

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abstract = "Vitamin B(12) (B(12)) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B(12) and folic acid on plasma total homocysteine (tHcy) concentration.",

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Deshmukh, US, Joglekar, CV, Lubree, HG, Ramdas, LV, Bhat, DS, Naik, SS, Hardikar, PS, Raut, DA, Konde, TB, Wills, AK, Jackson, AA, Refsum, H, Nanivadekar, AS, Fall, CH & Yajnik, CS 2010, 'Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India', European Journal of Clinical Nutrition, vol. 64, no. 5, pp. 495-502. https://doi.org/10.1038/ejcn.2010.15

TY - JOUR

T1 - Effect of physiological doses of oral vitamin B12 on plasma homocysteine

T2 - a randomized, placebo-controlled, double-blind trial in India

AU - Deshmukh, U S

AU - Joglekar, C V

AU - Lubree, H G

AU - Ramdas, L V

AU - Bhat, D S

AU - Naik, S S

AU - Hardikar, P S

AU - Raut, D A

AU - Konde, T B

AU - Wills, A K

AU - Jackson, A A

AU - Refsum, H

AU - Nanivadekar, A S

AU - Fall, C H

AU - Yajnik, C S

PY - 2010

Y1 - 2010

N2 - Vitamin B(12) (B(12)) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B(12) and folic acid on plasma total homocysteine (tHcy) concentration.

AB - Vitamin B(12) (B(12)) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B(12) and folic acid on plasma total homocysteine (tHcy) concentration.

U2 - 10.1038/ejcn.2010.15

DO - 10.1038/ejcn.2010.15

M3 - Article (Academic Journal)

C2 - 20216560

SN - 1476-5640

VL - 64

SP - 495

EP - 502

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 5

ER -

Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India

Abstract

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