Effect of preoperative administration of atenolol to dogs with pulmonic stenosis undergoing interventional procedures

Samantha Gomart*, Paul D Macfarlane, Jessie Rose Payne, Melanie J Hezzell, Kieran Borgeat

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)
217 Downloads (Pure)

Abstract

Background: Beta-blockade is sometimes used in dogs with pulmonic stenosis with the intent of reducing frequency of ventricular arrhythmias during right heart catheterization.

Objectives: To evaluate if pretreatment with atenolol reduces frequency of ventricular arrhythmias, anesthetist interventions, or shortens procedure time.

Animals: Thirty dogs with pulmonic stenosis scheduled for interventional procedures.

Methods: Single center, prospective, randomized, open-label study. Dogs were randomized to treatment with atenolol or no treatment preoperatively for a minimum of 10 days. Variables recorded included heart rate, arrhythmias and complexity, total procedure time and administration of antiarrhythmic treatment, vasopressors, positive chronotropes, or fluid boluses.

Results: Fifteen dogs were enrolled in each group. Dogs receiving atenolol had lower mean heart rates during the procedure (atenolol 100 ± 11 bpm vs untreated 115 ± 19 bpm, P = .01). There were no significant differences between the atenolol and untreated groups in the frequency of ventricular ectopic complexes (535 [6-5296] vs 553 [79-2863], P = .9), ventricular couplets (46 [0-481] vs 29 [3-121], P = .59), ventricular triplets (20 [0-265] vs 16 [1-82], P = .67), ventricular tachycardia (8 [0-224] vs 8 [1-118], P = .99), proportion exhibiting R-on-T phenomenon (11/15 vs 14/15, P = .33), proportion receiving intraoperative lidocaine (1/15 vs 3/15, P = .6), vasopressors/positive chronotropes (11/15 vs 5/15, P = .06), or fluid boluses (12/15 vs 7/15, P = .13). The procedure time was similar (atenolol 41 [23-68] min vs untreated 35 [18-98] min, P = .91).

Conclusions and clinical importance: No benefit of preoperative atenolol treatment was identified in this small group of dogs.
Original languageEnglish
Pages (from-to)877-885
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume36
Issue number3
Early online date18 Mar 2022
DOIs
Publication statusPublished - 18 Mar 2022

Bibliographical note

Funding Information:
Funding provided by a Langford Vets Clinical Research Fund internal grant. HeartVets facilitated batch analysis of intraoperative Holter ECG data by Express Diagnostics, Plymouth, UK.

Publisher Copyright:
© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

Keywords

  • balloon valvuloplasty
  • beta-blockers
  • intravascular stent
  • pulmonic stenosis

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