Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis

Tiffany Leung, Andrew Bergen, Marcus Robert Munafò, Kim De Ruyck, Peter Selby, Vincenzo De Luca

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)

Abstract

OBJECTIVE: To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT).

METHODS: We searched for NRT studies published from 2000-2013 that reported counts for allelic variation of rs16969968/rs1051730 and measured abstinence rates at the end of NRT treatment. We identified four studies which met the criteria, giving us a test sample of 2036 participants.

RESULTS: There was no effect of rs16969968/rs1051730 in influencing the success rate at the end of NRT (n = 6, effect size [ES]: 0.969, 95% CI: 0.77 to 1.23, z = 0.27, p = 0.791).

CONCLUSION: There is no robust evidence that allelic variations of rs16969968 or rs1051730 are associated with smoking cessation after NRT. Original submitted 26 November 2014; Revision submitted 9 March 2015.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalPharmacogenomics
DOIs
Publication statusPublished - 7 May 2015

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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