Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction

CL Trotter, NJ Andrews, EB Kaczmarski, E Miller, ME Ramsay

Research output: Contribution to journalArticle (Academic Journal)peer-review

480 Citations (Scopus)

Abstract

The meningococcal serogroup C conjugate (MCC) vaccine programme in England has successfully controlled the incidence of serogroup C disease, as a result of high short-term vaccine effectiveness and substantial herd immunity. However, the long-term effectiveness of the vaccine remains unknown. We assessed surveillance data from the 4 years since introduction of the programme. Vaccine effectiveness remained high in children vaccinated in the catch-up campaign (aged 5 months to 18 years). However, for children vaccinated in the routine infant immunisation programme, the effectiveness of the MCC vaccine fell to low levels after only 1 year. The number of individuals in these cohorts remains low, but alternative routine immunisation schedules should be considered to ensure high levels of protection are sustained.
Translated title of the contributionEffectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction
Original languageEnglish
Pages (from-to)365 - 367
Number of pages3
JournalLancet
Volume364 (9431)
DOIs
Publication statusPublished - 24 Jul 2004

Bibliographical note

Publisher: Elsevier

Fingerprint

Dive into the research topics of 'Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction'. Together they form a unique fingerprint.

Cite this