Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome

T van Amelsvoort, J Zinkstok, M Figee, E Daly, R Morris, M J Owen, K C Murphy, L De Haan, D H Linszen, B Glaser, D G M Murphy

Research output: Contribution to journalArticle (Academic Journal)peer-review

37 Citations (Scopus)

Abstract

Velo-cardio-facial syndrome (VCFS) is associated with deletions at chromosome 22q11, abnormalities in brain anatomy and function, and schizophrenia-like psychosis. Thus it is assumed that one or more genes within the deleted region are crucial to brain development. However, relatively little is known about how genetic variation at 22q11 affects brain structure and function. One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity. Here, we investigated the effect of COMT Val158Met polymorphism on brain anatomy and cognition in adults with VCFS.
Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalPsychological Medicine
Volume38
Issue number1
DOIs
Publication statusPublished - 2008

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