Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome

T van Amelsvoort; J Zinkstok; M Figee; E Daly; R Morris; M J Owen; K C Murphy; L De Haan; D H Linszen; B Glaser; D G M Murphy

doi:10.1017/S0033291707000700

Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome

T van Amelsvoort, J Zinkstok, M Figee, E Daly, R Morris, M J Owen, K C Murphy, L De Haan, D H Linszen, B Glaser, D G M Murphy

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Abstract

Velo-cardio-facial syndrome (VCFS) is associated with deletions at chromosome 22q11, abnormalities in brain anatomy and function, and schizophrenia-like psychosis. Thus it is assumed that one or more genes within the deleted region are crucial to brain development. However, relatively little is known about how genetic variation at 22q11 affects brain structure and function. One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity. Here, we investigated the effect of COMT Val158Met polymorphism on brain anatomy and cognition in adults with VCFS.

Original language	English
Pages (from-to)	89-100
Number of pages	12
Journal	Psychological Medicine
Volume	38
Issue number	1
DOIs	https://doi.org/10.1017/S0033291707000700
Publication status	Published - 2008

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title = "Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome",

abstract = "Velo-cardio-facial syndrome (VCFS) is associated with deletions at chromosome 22q11, abnormalities in brain anatomy and function, and schizophrenia-like psychosis. Thus it is assumed that one or more genes within the deleted region are crucial to brain development. However, relatively little is known about how genetic variation at 22q11 affects brain structure and function. One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity. Here, we investigated the effect of COMT Val158Met polymorphism on brain anatomy and cognition in adults with VCFS.",

author = "\{van Amelsvoort\}, T and J Zinkstok and M Figee and E Daly and R Morris and Owen, \{M J\} and Murphy, \{K C\} and \{De Haan\}, L and Linszen, \{D H\} and B Glaser and Murphy, \{D G M\}",

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doi = "10.1017/S0033291707000700",

language = "English",

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pages = "89--100",

journal = "Psychological Medicine",

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T1 - Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome

AU - van Amelsvoort, T

AU - Zinkstok, J

AU - Figee, M

AU - Daly, E

AU - Morris, R

AU - Owen, M J

AU - Murphy, K C

AU - De Haan, L

AU - Linszen, D H

AU - Glaser, B

AU - Murphy, D G M

PY - 2008

Y1 - 2008

N2 - Velo-cardio-facial syndrome (VCFS) is associated with deletions at chromosome 22q11, abnormalities in brain anatomy and function, and schizophrenia-like psychosis. Thus it is assumed that one or more genes within the deleted region are crucial to brain development. However, relatively little is known about how genetic variation at 22q11 affects brain structure and function. One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity. Here, we investigated the effect of COMT Val158Met polymorphism on brain anatomy and cognition in adults with VCFS.

AB - Velo-cardio-facial syndrome (VCFS) is associated with deletions at chromosome 22q11, abnormalities in brain anatomy and function, and schizophrenia-like psychosis. Thus it is assumed that one or more genes within the deleted region are crucial to brain development. However, relatively little is known about how genetic variation at 22q11 affects brain structure and function. One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity. Here, we investigated the effect of COMT Val158Met polymorphism on brain anatomy and cognition in adults with VCFS.

U2 - 10.1017/S0033291707000700

DO - 10.1017/S0033291707000700

M3 - Article (Academic Journal)

C2 - 17493297

SN - 0033-2917

VL - 38

SP - 89

EP - 100

JO - Psychological Medicine

JF - Psychological Medicine

IS - 1

ER -

Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome

Abstract

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