Effects of intestinal inflammation on fecal elastase concentration in dogs

IA Battersby, IR Peters, MJ Day, AJ German, EJ Hall

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)


BACKGROUND: A commercially available ELISA kit for fecal elastase measurement can be used in the diagnosis of exocrine pancreatic insufficiency (EPI) in dogs. However, other causes of diarrhea also may affect fecal elastase concentration. OBJECTIVE: This study was undertaken to determine whether intestinal inflammation alters fecal elastase concentration in dogs. METHODS: Fecal elastase concentration was measured with an ELISA kit in the following groups of dogs: group 1 (n=16), control dogs, without gastrointestinal disease; group 2 (n=14), dogs with diarrhea and no histopathologic evidence of intestinal inflammation; and group 3 (n=12), dogs with diarrhea and histopathologic evidence of intestinal inflammation. Serum trypsin-like immunoreactivity (TLI) was determined in dogs with diarrhea to rule out EPI. RESULTS: All dogs in groups 2 and 3 had serum TLI concentrations >5 microg/L, ruling out EPI. No statistically significant difference was found in fecal elastase concentration among the 3 groups of dogs (P=.969). CONCLUSIONS: The results indicate that intestinal inflammation does not affect fecal elastase concentration, such that test results may be used to exclude a diagnosis of EPI even in animals with inflammatory bowel disease.
Translated title of the contributionEffects of intestinal inflammation on fecal elastase concentration in dogs
Original languageEnglish
Pages (from-to)49 - 51
Number of pages3
JournalVeterinary Clinical Pathology
Volume34 (1)
Publication statusPublished - 2005

Bibliographical note

Publisher: American Society of Veterinary Clinical Pathology


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