Effects of MMP inhibitors incorporated within dental adhesives

A Almahdy, G Koller, S Sauro, J W Bartsch, M Sherriff, T F Watson, A Banerjee

Research output: Contribution to journalArticle (Academic Journal)peer-review

66 Citations (Scopus)


Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined the effect of including 2 MMP inhibitors (BB94 and GM6001) within the primers of 3 commercially available adhesives. Fluorometric assay and zymography showed that adhesives with MMP inhibitors had high affinity toward both synthetic fluorogenic FRET peptides (95%) and dentin powder substrates, respectively. The immediate microtensile bond strength was enhanced for 2 types of adhesives following the addition of both inhibitors. However, no changes were detected between the control and the inhibitor groups following 3-month storage. The modified two-step etch-and-rinse and single-step systems showed less Rhodamine B penetration to the "hybrid layer" and to the "adhesive", respectively. The incorporation of BB94 and GM6001 within the primers resulted in the inhibition of dentin MMPs with improved initial bond strength and enhanced sealing ability.
Original languageEnglish
Pages (from-to)605-11
Number of pages7
JournalJournal of Dental Research
Issue number6
Publication statusPublished - Jun 2012


  • Adolescent
  • Adult
  • Dental Bonding
  • Dental Leakage
  • Dental Stress Analysis
  • Dentin
  • Dentin-Bonding Agents
  • Dipeptides
  • Humans
  • Logistic Models
  • Materials Testing
  • Matrix Metalloproteinase Inhibitors
  • Methacrylates
  • Molar
  • Phenylalanine
  • Polymethacrylic Acids
  • Resin Cements
  • Tensile Strength
  • Thiophenes
  • Young Adult


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