Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight

John Macleod; Lie Tang; F. D. Richard Hobbs; Brian Wharton; Roger Holder; Shakir Hussain; Linda Nichols; Paul Stewart; Penny Clark; Steve Luzio; Jeffrey M P Holly; George Davey Smith

doi:10.1371/journal.pone.0083371

Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight

John Macleod^*, Lie Tang, F. D. Richard Hobbs, Brian Wharton, Roger Holder, Shakir Hussain, Linda Nichols, Paul Stewart, Penny Clark, Steve Luzio, Jeffrey M P Holly, George Davey Smith

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

Abstract

BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials from the more developed world have previously been reported.

OBJECTIVE: To test the hypothesis that nutritional supplementation during pregnancy influences offspring disease risk in adulthood.

DESIGN: Clinical assessment of a range of established diseases risk markers in young adult offspring of 283 South Asian mothers who participated in two trials of nutritional supplementation during pregnancy (protein/energy/vitamins; energy/vitamins or vitamins only) at Sorrento Maternity Hospital in Birmingham UK either unselected or selected on the basis of nutritional status.

RESULTS: 236 (83%) offspring were traced and 118 (50%) of these were assessed in clinic. Protein/energy/vitamins supplementation amongst undernourished mothers was associated with increased infant birthweight. Nutritional supplementation showed no strong association with any one of a comprehensive range of markers of adult disease risk and no consistent pattern of association with risk across markers in offspring of either unselected or undernourished mothers.

CONCLUSIONS: We found no evidence that nutritional supplements given to pregnant women are an important influence on adult disease risk however our study lacked power to estimate small effects. Our findings do not provide support for a policy of nutritional supplementation for pregnant women as an effective means to improve adult health in more developed societies.

Original language	English
Article number	83371
Number of pages	15
Journal	PLoS ONE
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0083371
Publication status	Published - 13 Dec 2013

Keywords

Adult
Asian Continental Ancestry Group
Dietary Proteins
Eating
Female
Follow-Up Studies
Humans
Male
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Vitamins

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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

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Macleod, J., Tang, L., Hobbs, F. D. R., Wharton, B., Holder, R., Hussain, S., Nichols, L., Stewart, P., Clark, P., Luzio, S., Holly, J. M. P., & Smith, G. D. (2013). Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight. PLoS ONE, 8(12), Article 83371. https://doi.org/10.1371/journal.pone.0083371

@article{46cb64c838ba479c8aa11b924f39b43a,

title = "Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight",

abstract = "BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials from the more developed world have previously been reported.OBJECTIVE: To test the hypothesis that nutritional supplementation during pregnancy influences offspring disease risk in adulthood.DESIGN: Clinical assessment of a range of established diseases risk markers in young adult offspring of 283 South Asian mothers who participated in two trials of nutritional supplementation during pregnancy (protein/energy/vitamins; energy/vitamins or vitamins only) at Sorrento Maternity Hospital in Birmingham UK either unselected or selected on the basis of nutritional status.RESULTS: 236 (83%) offspring were traced and 118 (50%) of these were assessed in clinic. Protein/energy/vitamins supplementation amongst undernourished mothers was associated with increased infant birthweight. Nutritional supplementation showed no strong association with any one of a comprehensive range of markers of adult disease risk and no consistent pattern of association with risk across markers in offspring of either unselected or undernourished mothers.CONCLUSIONS: We found no evidence that nutritional supplements given to pregnant women are an important influence on adult disease risk however our study lacked power to estimate small effects. Our findings do not provide support for a policy of nutritional supplementation for pregnant women as an effective means to improve adult health in more developed societies.",

keywords = "Adult, Asian Continental Ancestry Group, Dietary Proteins, Eating, Female, Follow-Up Studies, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Vitamins",

author = "John Macleod and Lie Tang and Hobbs, {F. D. Richard} and Brian Wharton and Roger Holder and Shakir Hussain and Linda Nichols and Paul Stewart and Penny Clark and Steve Luzio and Holly, {Jeffrey M P} and Smith, {George Davey}",

year = "2013",

month = dec,

day = "13",

doi = "10.1371/journal.pone.0083371",

language = "English",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "12",

}

Macleod, J, Tang, L, Hobbs, FDR, Wharton, B, Holder, R, Hussain, S, Nichols, L, Stewart, P, Clark, P, Luzio, S, Holly, JMP & Smith, GD 2013, 'Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight', PLoS ONE, vol. 8, no. 12, 83371. https://doi.org/10.1371/journal.pone.0083371

Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight. / Macleod, John; Tang, Lie; Hobbs, F. D. Richard et al.
In: PLoS ONE, Vol. 8, No. 12, 83371, 13.12.2013.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight

AU - Macleod, John

AU - Tang, Lie

AU - Hobbs, F. D. Richard

AU - Wharton, Brian

AU - Holder, Roger

AU - Hussain, Shakir

AU - Nichols, Linda

AU - Stewart, Paul

AU - Clark, Penny

AU - Luzio, Steve

AU - Holly, Jeffrey M P

AU - Smith, George Davey

PY - 2013/12/13

Y1 - 2013/12/13

N2 - BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials from the more developed world have previously been reported.OBJECTIVE: To test the hypothesis that nutritional supplementation during pregnancy influences offspring disease risk in adulthood.DESIGN: Clinical assessment of a range of established diseases risk markers in young adult offspring of 283 South Asian mothers who participated in two trials of nutritional supplementation during pregnancy (protein/energy/vitamins; energy/vitamins or vitamins only) at Sorrento Maternity Hospital in Birmingham UK either unselected or selected on the basis of nutritional status.RESULTS: 236 (83%) offspring were traced and 118 (50%) of these were assessed in clinic. Protein/energy/vitamins supplementation amongst undernourished mothers was associated with increased infant birthweight. Nutritional supplementation showed no strong association with any one of a comprehensive range of markers of adult disease risk and no consistent pattern of association with risk across markers in offspring of either unselected or undernourished mothers.CONCLUSIONS: We found no evidence that nutritional supplements given to pregnant women are an important influence on adult disease risk however our study lacked power to estimate small effects. Our findings do not provide support for a policy of nutritional supplementation for pregnant women as an effective means to improve adult health in more developed societies.

AB - BACKGROUND: Observational evidence suggests that improving fetal growth may improve adult health. Experimental evidence from nutritional supplementation trials undertaken amongst pregnant women in the less developed world does not show strong or consistent effects on adult disease risk and no trials from the more developed world have previously been reported.OBJECTIVE: To test the hypothesis that nutritional supplementation during pregnancy influences offspring disease risk in adulthood.DESIGN: Clinical assessment of a range of established diseases risk markers in young adult offspring of 283 South Asian mothers who participated in two trials of nutritional supplementation during pregnancy (protein/energy/vitamins; energy/vitamins or vitamins only) at Sorrento Maternity Hospital in Birmingham UK either unselected or selected on the basis of nutritional status.RESULTS: 236 (83%) offspring were traced and 118 (50%) of these were assessed in clinic. Protein/energy/vitamins supplementation amongst undernourished mothers was associated with increased infant birthweight. Nutritional supplementation showed no strong association with any one of a comprehensive range of markers of adult disease risk and no consistent pattern of association with risk across markers in offspring of either unselected or undernourished mothers.CONCLUSIONS: We found no evidence that nutritional supplements given to pregnant women are an important influence on adult disease risk however our study lacked power to estimate small effects. Our findings do not provide support for a policy of nutritional supplementation for pregnant women as an effective means to improve adult health in more developed societies.

KW - Adult

KW - Asian Continental Ancestry Group

KW - Dietary Proteins

KW - Eating

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Risk Factors

KW - Vitamins

U2 - 10.1371/journal.pone.0083371

DO - 10.1371/journal.pone.0083371

M3 - Article (Academic Journal)

C2 - 24349496

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 12

M1 - 83371

ER -

Effects of Nutritional Supplementation during Pregnancy on Early Adult Disease Risk: Follow Up of Offspring of Participants in a Randomised Controlled Trial Investigating Effects of Supplementation on Infant Birth Weight

Abstract

Keywords

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