Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning

Jun-Hyeok Choi, Pojeong Park, GC Baek, Su-Eon Sim, Joshua Kang, Yeseul Lee, Seo-Hee Ahn, Chae-Seok Lim, Yong-Seok Lee, Graham Collingridge, Bong-Kiun Kaang

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Previous studies have shown that a family of phosphoinositide 3-kinases (PI3Ks) plays pivotal roles in the brain; in particular, we previously reported that knockout of the γ isoform of PI3K (PI3Kγ) in mice impaired synaptic plasticity and reduced behavioral flexibility. To further examine the role of PI3Kγ in synaptic plasticity and hippocampus-dependent behavioral tasks we overexpressed p110γ, the catalytic subunit of PI3Kγ, in the hippocampal CA1 region. We found that the overexpression of p110γ impairs NMDA receptor-dependent long-term depression (LTD) and hippocampus-dependent spatial learning in the Morris water maze (MWM) task. In contrast, long-term potentiation (LTP) and contextual fear memory were not affected by p110γ overexpression. These results, together with the previous knockout study, suggest that a critical level of PI3Kγ in the hippocampus is required for successful induction of LTD and normal learning.
Original languageEnglish
Article number78
Number of pages8
JournalMolecular Brain
Volume7
DOIs
Publication statusPublished - 6 Nov 2014

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