Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study

Anna Chaimani; Haris S Vasiliadis; Nikolaos Pandis; Christopher H Schmid; Nicky J Welton; Georgia Salanti

doi:10.1093/ije/dyt074

Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study

Anna Chaimani, Haris S Vasiliadis, Nikolaos Pandis, Christopher H Schmid, Nicky J Welton, Georgia Salanti

Research output: Contribution to journal › Article (Academic Journal) › peer-review

56 Citations (Scopus)

Abstract

Empirical research has illustrated an association between study size and relative treatment effects, but conclusions have been inconsistent about the association of study size with the risk of bias items. Small studies give generally imprecisely estimated treatment effects, and study variance can serve as a surrogate for study size.

Original language	English
Journal	International Journal of Epidemiology
DOIs	https://doi.org/10.1093/ije/dyt074
Publication status	Published - 27 Jun 2013

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MRC METHODOLOGY RESEARCH FELLOWSHIP
Welton, N. J. (Principal Investigator)
4/05/09 → 4/11/13
Project: Research
COLLABORATION AND INNOVATION IN DIFFICULT OR RANDOMISED CONTROLLED TRIALS
Blazeby, J. (Principal Investigator)
1/04/09 → 1/04/14
Project: Research

Cite this

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title = "Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study",

abstract = "Empirical research has illustrated an association between study size and relative treatment effects, but conclusions have been inconsistent about the association of study size with the risk of bias items. Small studies give generally imprecisely estimated treatment effects, and study variance can serve as a surrogate for study size.",

author = "Anna Chaimani and Vasiliadis, {Haris S} and Nikolaos Pandis and Schmid, {Christopher H} and Welton, {Nicky J} and Georgia Salanti",

year = "2013",

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language = "English",

journal = "International Journal of Epidemiology",

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AU - Chaimani, Anna

AU - Vasiliadis, Haris S

AU - Pandis, Nikolaos

AU - Schmid, Christopher H

AU - Welton, Nicky J

AU - Salanti, Georgia

PY - 2013/6/27

Y1 - 2013/6/27

N2 - Empirical research has illustrated an association between study size and relative treatment effects, but conclusions have been inconsistent about the association of study size with the risk of bias items. Small studies give generally imprecisely estimated treatment effects, and study variance can serve as a surrogate for study size.

AB - Empirical research has illustrated an association between study size and relative treatment effects, but conclusions have been inconsistent about the association of study size with the risk of bias items. Small studies give generally imprecisely estimated treatment effects, and study variance can serve as a surrogate for study size.

U2 - 10.1093/ije/dyt074

DO - 10.1093/ije/dyt074

M3 - Article (Academic Journal)

C2 - 23811232

SN - 0300-5771

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

ER -

Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study

Abstract

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Projects

MRC METHODOLOGY RESEARCH FELLOWSHIP

COLLABORATION AND INNOVATION IN DIFFICULT OR RANDOMISED CONTROLLED TRIALS

Cite this