Effects of tracer arrival time on the accuracy of high-resolution (voxel-wise) myocardial perfusion maps from contrast-enhanced first-pass perfusion magnetic resonance

Niloufar Zarinabad, Gilion L T F Hautvast, Eva Sammut, Aruna Arujuna, Marcel Breeuwer, Eike Nagel, Amedeo Chiribiri

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

First-pass perfusion cardiac magnetic resonance(CMR) allows the quantitative assessment of myocardial blood flow(MBF). However, flow estimates are sensitive to the delay between the arterial and myocardial tissue tracer arrival time (tOnset) and the accurate estimation of MBF relies on the precise identification of tOnset . The aim of this study is to assess the sensitivity of the quantification process to tOnset at voxel level. Perfusion data were obtained from series of simulated data, a hardware perfusion phantom, and patients. Fermi deconvolution has been used for analysis. A novel algorithm, based on sequential deconvolution,which minimizes the error between myocardial curves and fitted curves obtained after deconvolution, has been used to identify the optimal tOnset for each region. Voxel-wise analysis showed to be more sensitive to tOnset compared to segmental analysis. The automated detection of the tOnset allowed a net improvement of the accuracy of MBF quantification and in patients the identification of perfusion abnormalities in territories that were missed when a constant user-selected tOnset was used. Our results indicate that high-resolution MBF quantification should be performed with optimized tOnset values at voxel level.

Original languageEnglish
Pages (from-to)2499-2506
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume61
Issue number9
DOIs
Publication statusPublished - Sep 2014

Keywords

  • Cardiac Imaging Techniques/methods
  • Case-Control Studies
  • Computer Simulation
  • Contrast Media/pharmacokinetics
  • Coronary Artery Disease/physiopathology
  • Coronary Circulation/physiology
  • Humans
  • Magnetic Resonance Angiography/methods
  • Perfusion Imaging/methods
  • Phantoms, Imaging

Fingerprint Dive into the research topics of 'Effects of tracer arrival time on the accuracy of high-resolution (voxel-wise) myocardial perfusion maps from contrast-enhanced first-pass perfusion magnetic resonance'. Together they form a unique fingerprint.

Cite this