Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial.

Ozlem Gögebakan, Angela Kohl, Martin A Osterhoff, Marleen A van Baak, Susan A Jebb, Angeliki Papadaki, J Alfredo Martinez, Teodora Handjieva-Darlenska, Petr Hlavaty, Martin O Weickert, Claus Holst, Wim H M Saris, Arne Astrup, Andreas F H Pfeiffer, DiOGenes

Research output: Contribution to journalArticle (Academic Journal)peer-review

140 Citations (Scopus)

Abstract

BACKGROUND:
We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes).
METHODS AND RESULTS:
DiOGenes is a pan-European controlled dietary intervention study in 932 overweight adults who first lost body weight on an 8-week low-calorie diet and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high or low protein or high or low glycemic index in 4 combinations or control. Weight loss (-11.23 kg; 95% confidence interval, -11.54 to -10.92; P<0.001) reduced high-sensitivity C-reactive protein (-1.15 mg/L; 95% confidence interval, -1.30 to -0.41; P<0.001), low- and high-density lipoprotein cholesterol, triglycerides, and blood pressure. During the 26-week weight maintenance period in the intention-to-treat analysis, the further decrease of high-sensitivity C-reactive protein blood levels was -0.46 mg/L greater (95% confidence interval, -0.79 to -0.13) in the groups assigned to low-glycemic-index diets than in those on high-glycemic-index diets (P<0.001). Groups on low-protein diets achieved a -0.25 mg/L greater reduction in high-sensitivity C-reactive protein (95% confidence interval, -0.59 to -0.17) than those on high-protein diets (P<0.001), whereas lipid profiles and blood pressure were not differently affected.
CONCLUSIONS:
This large-scale intervention study clearly separates weight loss from dietary composition-related effects. Low-glycemic-index carbohydrates and, to a lesser extent, low-protein intake may specifically reduce low-grade inflammation and associated comorbidities in overweight/obese adults.
CLINICAL TRIAL REGISTRATION:
http://www.clinicaltrials.gov. Unique identifier: NCT00390637.
Original languageEnglish
Pages (from-to)2829-38
Number of pages10
JournalCirculation
Volume124
Issue number25
DOIs
Publication statusPublished - Nov 2011

Fingerprint Dive into the research topics of 'Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial.'. Together they form a unique fingerprint.

Cite this