Efficacy of iron and/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren: a randomized, placebo-controlled trial

Javier Alatorre Rico, Katarzyna Kordas, Patricia López, Jorge L Rosado, Gonzalo García Vargas, Dolores Ronquillo, Rebecca J Stoltzfus

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Abstract

Lead exposure in children has been associated with both global and specific cognitive deficits. Although chelation therapy is advised for children with blood lead concentrations of >44 microg/dL, treatment options for children with lower blood lead values are limited. Because lead absorption is related to children's nutritional status, micronutrient supplements may be 1 strategy for combating low-level, chronic lead exposure. This study was designed to test the efficacy of iron and zinc supplementation for lowering blood lead concentrations and improving cognitive performance in schoolchildren who live in a lead-contaminated city.
Original languageEnglish
Pages (from-to)e518-27
JournalPediatrics
Volume117
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Child
  • Cognition
  • Double-Blind Method
  • Drug Therapy, Combination
  • Educational Status
  • Environmental Exposure
  • Female
  • Ferritins
  • Ferrous Compounds
  • Humans
  • Intelligence Tests
  • Lead
  • Male
  • Metallurgy
  • Zinc
  • Zinc Oxide

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