Efficacy of iron and/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren: a randomized, placebo-controlled trial

Javier Alatorre Rico; Katarzyna Kordas; Patricia López; Jorge L Rosado; Gonzalo García Vargas; Dolores Ronquillo; Rebecca J Stoltzfus

doi:10.1542/peds.2005-1172

Efficacy of iron and/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren: a randomized, placebo-controlled trial

Javier Alatorre Rico, Katarzyna Kordas, Patricia López, Jorge L Rosado, Gonzalo García Vargas, Dolores Ronquillo, Rebecca J Stoltzfus

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

36 Citations (Scopus)

Abstract

Lead exposure in children has been associated with both global and specific cognitive deficits. Although chelation therapy is advised for children with blood lead concentrations of >44 microg/dL, treatment options for children with lower blood lead values are limited. Because lead absorption is related to children's nutritional status, micronutrient supplements may be 1 strategy for combating low-level, chronic lead exposure. This study was designed to test the efficacy of iron and zinc supplementation for lowering blood lead concentrations and improving cognitive performance in schoolchildren who live in a lead-contaminated city.

Original language	English
Pages (from-to)	e518-27
Journal	Pediatrics
Volume	117
Issue number	3
DOIs	https://doi.org/10.1542/peds.2005-1172
Publication status	Published - Mar 2006

Keywords

Child
Cognition
Double-Blind Method
Drug Therapy, Combination
Educational Status
Environmental Exposure
Female
Ferritins
Ferrous Compounds
Humans
Intelligence Tests
Lead
Male
Metallurgy
Zinc
Zinc Oxide

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title = "Efficacy of iron and/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren: a randomized, placebo-controlled trial",

abstract = "Lead exposure in children has been associated with both global and specific cognitive deficits. Although chelation therapy is advised for children with blood lead concentrations of >44 microg/dL, treatment options for children with lower blood lead values are limited. Because lead absorption is related to children's nutritional status, micronutrient supplements may be 1 strategy for combating low-level, chronic lead exposure. This study was designed to test the efficacy of iron and zinc supplementation for lowering blood lead concentrations and improving cognitive performance in schoolchildren who live in a lead-contaminated city.",

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author = "Rico, {Javier Alatorre} and Katarzyna Kordas and Patricia L{\'o}pez and Rosado, {Jorge L} and Vargas, {Gonzalo Garc{\'i}a} and Dolores Ronquillo and Stoltzfus, {Rebecca J}",

year = "2006",

month = mar,

doi = "10.1542/peds.2005-1172",

language = "English",

volume = "117",

pages = "e518--27",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

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TY - JOUR

T1 - Efficacy of iron and/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren

T2 - a randomized, placebo-controlled trial

AU - Rico, Javier Alatorre

AU - Kordas, Katarzyna

AU - López, Patricia

AU - Rosado, Jorge L

AU - Vargas, Gonzalo García

AU - Ronquillo, Dolores

AU - Stoltzfus, Rebecca J

PY - 2006/3

Y1 - 2006/3

N2 - Lead exposure in children has been associated with both global and specific cognitive deficits. Although chelation therapy is advised for children with blood lead concentrations of >44 microg/dL, treatment options for children with lower blood lead values are limited. Because lead absorption is related to children's nutritional status, micronutrient supplements may be 1 strategy for combating low-level, chronic lead exposure. This study was designed to test the efficacy of iron and zinc supplementation for lowering blood lead concentrations and improving cognitive performance in schoolchildren who live in a lead-contaminated city.

AB - Lead exposure in children has been associated with both global and specific cognitive deficits. Although chelation therapy is advised for children with blood lead concentrations of >44 microg/dL, treatment options for children with lower blood lead values are limited. Because lead absorption is related to children's nutritional status, micronutrient supplements may be 1 strategy for combating low-level, chronic lead exposure. This study was designed to test the efficacy of iron and zinc supplementation for lowering blood lead concentrations and improving cognitive performance in schoolchildren who live in a lead-contaminated city.

KW - Child

KW - Cognition

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Educational Status

KW - Environmental Exposure

KW - Female

KW - Ferritins

KW - Ferrous Compounds

KW - Humans

KW - Intelligence Tests

KW - Lead

KW - Male

KW - Metallurgy

KW - Zinc

KW - Zinc Oxide

U2 - 10.1542/peds.2005-1172

DO - 10.1542/peds.2005-1172

M3 - Article (Academic Journal)

C2 - 16510631

SN - 0031-4005

VL - 117

SP - e518-27

JO - Pediatrics

JF - Pediatrics

IS - 3

ER -

Efficacy of iron and/or zinc supplementation on cognitive performance of lead-exposed Mexican schoolchildren: a randomized, placebo-controlled trial

Abstract

Keywords

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