(Chemical Equation Presented) Treatment of N-arylisonicotinamides with trifluoromethanesulfonic anhydride triggers intramolecular nucleophilic attack of the aryl ring on the 4-position of the pyridinium intermediate. The products are spirocyclic dihydropyridines which can be converted to valuable spirocyclic piperidines related to biologically active molecules such as MK-677.
|Number of pages||4|
|Early online date||14 Jun 2008|
|Publication status||Published - 17 Jul 2008|