Electrophysiological evidence for an excitatory projection from ventromedial forebrain structures on to raphe- and reticulo-spinal neurones in the rat

BM Lumb, JFB Morrison

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)

Abstract

Spinally projecting neurones in nucleus raphe magnus (NRM) and the adjacent reticular formation of the medulla were identified by their antidromic responses to electrical stimulation in the lumbosacral spinal cord. Identified raphe-spinal and reticulo-spinal neurones were then tested for the effects of electrical stimulation at sites in the ventromedial forebrain, including the anterior hypothalamus and preoptic area (AH/POA). The results of these experiments have demonstrated that a considerable proportion of raphe- and reticulo-spinal neurones receive an excitatory input from the AH/POA. It is suggested that activity in this descending pathway might contribute to the inhibitory effects of AH/POA stimulation on the nociceptor-evoked activities of spinal dorsal horn neurones
Translated title of the contributionElectrophysiological evidence for an excitatory projection from ventromedial forebrain structures on to raphe- and reticulo-spinal neurones in the rat
Original languageEnglish
Pages (from-to)162 - 166
Number of pages4
JournalBrain Research
Volume380
DOIs
Publication statusPublished - Aug 2010

Fingerprint Dive into the research topics of 'Electrophysiological evidence for an excitatory projection from ventromedial forebrain structures on to raphe- and reticulo-spinal neurones in the rat'. Together they form a unique fingerprint.

Cite this