Projects per year
Abstract
Unlike in older people it has been suggested that elevated blood pressure (BP) in young people is due to high cardiac output (CO) accompanied by normal total peripheral resistance - a hyperkinetic/hyperdynamic circulation. We investigated this in a large, UK-based birth cohort of adolescents. The study was conducted on 2091 17 year old participants in the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective population-based birth cohort study. BP measurement and echocardiography were performed and heart rate (HR), stroke volume (SV) and total peripheral resistance (TPR) calculated. Data are means (SD).
Higher quintiles of systolic BP were associated with higher SV, higher HR and higher TPR. The proportional contribution made by SV, HR and TPR to mean arterial pressure differed little by systolic BP quintile (stroke volume (32-34%) heart rate (25-29%) and TPR (39-41%). Higher blood pressure is attributable to a combination of higher cardiac output (i.e. SV x HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated CO at higher BP levels.
Higher quintiles of systolic BP were associated with higher SV, higher HR and higher TPR. The proportional contribution made by SV, HR and TPR to mean arterial pressure differed little by systolic BP quintile (stroke volume (32-34%) heart rate (25-29%) and TPR (39-41%). Higher blood pressure is attributable to a combination of higher cardiac output (i.e. SV x HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated CO at higher BP levels.
Original language | English |
---|---|
Pages (from-to) | 1103-1108 |
Number of pages | 6 |
Journal | Hypertension |
Volume | 72 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Oct 2018 |
Keywords
- blood pressure
- cardiac output
- heart rate
- stroke volume
- total peripheral resistance
- hyperkinetic
- adolescence
Fingerprint
Dive into the research topics of 'Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State'. Together they form a unique fingerprint.Projects
- 5 Finished
-
Laura Howe Population Health Scientist Fellowship
Howe, L. D. (Principal Investigator)
1/09/15 → 31/12/22
Project: Research
-
Lifecourse epidemiology of female reproductive health and its relation to chronic disease
Fraser, A. (Principal Investigator)
1/12/14 → 20/02/20
Project: Research
-
MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research