Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State

Chloe Park, Abigail Fraser, Laura Howe, Siana Jones, George Davey Smith, Debbie Lawlor, Nish Chaturvedi, Alun D. Hughes

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
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Abstract

Unlike in older people it has been suggested that elevated blood pressure (BP) in young people is due to high cardiac output (CO) accompanied by normal total peripheral resistance - a hyperkinetic/hyperdynamic circulation. We investigated this in a large, UK-based birth cohort of adolescents. The study was conducted on 2091 17 year old participants in the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective population-based birth cohort study. BP measurement and echocardiography were performed and heart rate (HR), stroke volume (SV) and total peripheral resistance (TPR) calculated. Data are means (SD).
Higher quintiles of systolic BP were associated with higher SV, higher HR and higher TPR. The proportional contribution made by SV, HR and TPR to mean arterial pressure differed little by systolic BP quintile (stroke volume (32-34%) heart rate (25-29%) and TPR (39-41%). Higher blood pressure is attributable to a combination of higher cardiac output (i.e. SV x HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated CO at higher BP levels.
Original languageEnglish
Pages (from-to)1103-1108
Number of pages6
JournalHypertension
Volume72
Issue number5
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • blood pressure
  • cardiac output
  • heart rate
  • stroke volume
  • total peripheral resistance
  • hyperkinetic
  • adolescence

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