Embedding supervised exercise training for men on androgen deprivation therapy into standard prostate cancer care: a feasibility and acceptability study (the STAMINA trial)

Sophie Reale, Rebecca R Turner, Eileen Sutton, Liz Steed, Stephanie J C Taylor, Dylan Morrissey, Patrick Doherty, Diana M Greenfield, Michelle Collinson, Jenny Hewison, Janet Brown, Saïd Ibeggazene, Malcolm Mason, Derek J Rosario, Liam Bourke

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Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training intervention into standard prostate cancer care in a single-arm, multicentre prospective cohort study. Feasibility included recruitment, retention, adherence, fidelity and safety. Acceptability of behaviourally informed healthcare and exercise professional training was assessed qualitatively. Despite the imposition of lockdown for the COVID-19 pandemic, referral rates into and adherence to, the intervention was high. Of the 45 men eligible for participation, 79% (n = 36) received the intervention and 47% (n = 21) completed the intervention before a government mandated national lockdown was enforced in the United Kingdom. Patients completed a mean of 27 min of aerobic exercise per session (SD = 3.48), at 77% heart rate maximum (92% of target dose), and 3 sets of 10 reps of 3 resistance exercises twice weekly for 12 weeks, without serious adverse event. The intervention was delivered by 26 healthcare professionals and 16 exercise trainers with moderate to high fidelity, and the intervention was deemed highly acceptable to patients. The impact of societal changes due to the pandemic on the delivery of this face-to-face intervention remain uncertain but positive impacts of embedding exercise provision into prostate cancer care warrant long-term investigation.

Original languageEnglish
Article number12470
Number of pages12
JournalScientific Reports
Publication statusPublished - 14 Jun 2021

Bibliographical note

Funding Information:
This work was supported by the National Institute of Health Research [Grant Number RP-PG-1016-20007].

Funding Information:
The authors declare one competing interest. Professor Janet Brown reports: personal fees from Novartis, Amgen, BMS, Ipsen, MSD, Daiichi-Sankyo, Sandoz, Bayer and institutional grants from Amgen, Bayer, outside the submitted work.

Funding Information:
Study design. The present study was a single-arm multicentre interventional cohort study (18/03/2019, ISRCTN15691664) designed to examine the acceptability and feasibility of integrating and delivering exercise into standard prostate cancer care, as part of our intervention development process. This study contributes to a larger body of work; Supported exercise TrAining for Men with prostate caNcer on Androgen deprivation therapy (STAMINA—a National Institute of Health Research funded programme grant for applied research). In STAMINA we propose to embed our behaviourally informed and evidence-based lifestyle intervention into prostate cancer care. This involves training cancer team members to endorse and support exercise, community-based exercise trainers (ETs) to deliver supervised exercise and behavioural support and communication between them to provide seamless patient care (see supplementary file 1).

Publisher Copyright:
© 2021, The Author(s).


  • health care
  • psychology
  • urology


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