Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction

SAR Martin, KA Wilkinson, A Nishimune, JM Henley

Research output: Contribution to journalArticle (Academic Journal)peer-review

158 Citations (Scopus)

Abstract

Post-translational protein modifications are integral components of signalling cascades that enable cells to efficiently, rapidly and reversibly respond to extracellular stimuli. These modifications have crucial roles in the CNS, where the communication between neurons is particularly complex. SUMOylation is a post-translational modification in which a member of the small ubiquitin-like modifier (SUMO) family of proteins is conjugated to lysine residues in target proteins. It is well established that SUMOylation controls many aspects of nuclear function, but it is now clear that it is also a key determinant in many extranuclear neuronal processes, and it has also been implicated in a wide range of neuropathological conditions.
Translated title of the contributionEmerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction
Original languageEnglish
Pages (from-to)948 - 959
Number of pages12
JournalNature Reviews Neuroscience
Volume8 (12)
DOIs
Publication statusPublished - Dec 2007

Bibliographical note

Publisher: Nature Publishing Group
Other: Review

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